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Role of Platelet Rich Plasma in Bone Regeneration After Enucleation of Odontogenic Jaw Cysts

Role of Platelet Rich Plasma in Bone Regeneration After Enucleation of Odontogenic Jaw Cysts

Status
Not yet recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06721806
Enrollment
42
Registered
2024-12-06
Start date
2024-12-31
Completion date
2027-11-30
Last updated
2024-12-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PRP & Jaw Cysts

Brief summary

in the present study, the effect of PRP on bone regeneration when applied to the site of removal of cyst of the jaws is evaluated. PRP was delivered to the site combined with gelfoam. Thrombin clot accelerator was not used.

Detailed description

Jaw cysts are common lesions in the oral and maxillofacial region. Enucleation of cyst wall & curettage has evolved as the treatment of choice. In order to reduce infections and to accelerate bone regeneration, by using of Platelet rich plasma. Platelets are involved in regeneration at sites of pathology, apart from their role in clotting. A preparation composed mainly of platelets (platelet-rich plasma gel) applied to sites of bony pathology, after surgical treatment of lesions, may hasten bone regeneration. An interesting idea developed that the addition of a concentrate of platelets, to wounded tissues or surgical sites, may enhance the body's natural wound healing mechanisms . Platelet-rich plasma (PRP) is the accepted term to describe the preparation made out of autologous platelets suspended in autologous plasma, in concentration greater than normally found in peripheral blood Because it is autologous, PRP avoids the risk of transmissible diseases such as HIV, Hepatitis B, C or D and other blood-borne pathogens .A clot accelerator such as bovine thrombin is added to gel the PRP or PRP is added to other materials such as collagen, gelfoam, etc.

Interventions

PROCEDUREPRP & bone regeneration

PRP effect on bone healing

Sponsors

Assiut University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
Yes

Inclusion criteria

1. Size of the cyst more than 2 cm 2. The lesion could be visualized radiographically 3. Patients within the age range of 20 to 50 years

Exclusion criteria

1. Patients who were alcoholics & smokers 2. -Patients with systemic diseases 3. History of bleeding tendencies, blood dyscrasia 4. Low platelet count 5. Patients unable or unwilling to return for follow-up

Design outcomes

Primary

MeasureTime frameDescription
bone healing6 monthseffect of PRP in bone healing by measuring bone density
PRP & infection rate6 monthsPRP reduce infection rate

Contacts

Primary ContactMaikel M G Morkos, dr
Michael.16266363@med.aun.edu.eg+201271267725
Backup ContactSamy Masoud, prof .dr
samyosman@aun.edu.eg

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026