Blood Transfusion, Heart Surgery, Hemolysis
Conditions
Brief summary
This study aims to learn more about blood management in children undergoing heart surgery, such as the right amounts, and the best blood products, to administer. It also aims to develop a mathematical model that may help researchers better predict and treat patients who need blood transfusions during heart surgery.
Interventions
OTHERblood sampling
Discarded blood samples will be taken from routine clinical labs drawn during and after heart surgery.
Sponsors
Boston Children's Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
0 Years to 17 Years
Healthy volunteers
No
Inclusion criteria
* pediatric patients under 18 years of age undergoing cardiac surgery with clear prime on cardio-pulmonary bypass (CPB) at Boston Children's Hospital (BCH).
Exclusion criteria
* patients with known hemolytic disorders, patients on nitric oxide preoperatively, and patients found to have abnormal coagulation on routine preoperative assessment. Patients receiving heparin, American Society of Anesthesia (ASA) status, apixaban, warfarin, or bivalirudin held appropriately (i.e. for elective surgery) will not be excluded
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative hemolysis during pediatric cardiac cardio-pulmonary bypass (CPB) cases as assessed using the plasma free hemoglobin assessment | 1 day (during cardio-pulmonary bypass) |
Secondary
| Measure | Time frame |
|---|---|
| In vitro salvaged red blood cells (RBCs) co-incubation with patients' plasma for hemolysis assessment compared to patients' baseline RBCs | 1 day |
Countries
United States
Contacts
Primary ContactJocelyn Booth, BSN
Backup ContactRachel Bernier, MPH
Outcome results
None listed