Cavernous Sinus Lesions, Cavernous Sinus Meningioma, Cavernous Sinus Syndrome
Conditions
Keywords
Cavernous Sinus Syndromes, Ophthalmoplegia, Positron Emission Tomography Computed Tomography, Fluorodeoxyglucose F18, Cavernous Sinus
Brief summary
Cavernous sinus syndrome (CSS) can be caused by a wide range of inflammatory, malignant, benign, vascular and miscellaneous disorders. Even after modern advances, reaching the final etiological diagnosis remains a challenge in CSS. This study is planned to determine the role and incremental value of 18F-FDG PET/CT in characterising different cavernous sinus pathologies based on their metabolic activity and detecting extracranial involvement.
Interventions
DIAGNOSTIC_TESTFDG radiotracer
Pilot study evaluating the role of FDG PET/CT in Cavernous sinus syndrome
Sponsors
Post Graduate Institute of Medical Education and Research, Chandigarh
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients with age greater than or equal to 18 years, 2. with newly diagnosed CSS, 3. lesion seen on MRI in the CS, and 4. willing to give written informed consent.
Exclusion criteria
1. Pregnant and lactating patients 2. Patients already being treated (including steroids)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| SUVmax of the cavernous sinus lesions on FDG PET/CT | From enrollment to the establishment of final diagnosis upto a period of three months | Standardized uptake value (SUV) will be calculated by drawing region of interest (ROI) in the cavernous sinus region both on the whole body and the dedicated brain image, while carefully excluding normal brain activity. If lesions in the bilateral cavernous sinuses will be present, SUVmax of both the lesions will be noted. |
| Number of patients with extracranial sites of involvement on FDG PET/CT | From enrollment to the establishment of final diagnosis upto 3 months | — |
Countries
India
Outcome results
None listed