OCD
Conditions
Keywords
ocd, sleep, light therapy, circadian, behavioral treatment
Brief summary
The goal of this clinical trial is to test whether light therapy is effective for reducing symptoms in young adults with OCD and late bedtimes (1am or later). The main question\[s\] it aims to answer are: Does light therapy reduce OCD symptoms? Does light therapy advance the circadian clock? If there is a comparison group: Researchers will compare a higher dose of light therapy to a lower dose to see if dose amount affects symptom reduction. Participants will asked to: 1. Wear light therapy glasses for 1 hour each morning and complete a daily light therapy log for 5 weeks 2. Track their sleep every day with a wearable monitor and an electronic sleep diary for 5 weeks 3. Complete a 1-time assessment of sensitivity to light exposure 4. Complete self-report measures of OCD 4 times/day at baseline (2 weeks), mid-treatment (1 week), and end of treatment (1 week)
Interventions
BEHAVIORALLight therapy
5 weeks of light therapy administered via wearable light therapy glasses worn for 1 hour each morning after awakening.
Sponsors
Washington University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
17 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
1. Primary DSM-5 OCD diagnosis 2. Bedtime 0100 or later 3. Age 18-35 4. English speaking
Exclusion criteria
1. Subjects must not be currently participating in another research study that would influence their participation in our study. 2. Diagnostic status 3. Treatment status 4. Night shift work or travel more than 1 time zone outside of Central Standard Time (CST) in the past month 5. Pregnancy status 6. Medication status 7. Regular nicotine or marijuana use
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Yale Brown Obsessive-Compulsive Scale (YBOCS) | Administered at baseline, in treatment week 3, and post-treatment (3 administrations over 7 weeks) | A retrospective clinical interview of OCD symptom severity. Score range from 0 to 40 and higher scores indicate more severe OCD symptoms. |
| Daily Perseverative Thinking Questionnaire | Administered 4 times/day for 2 weeks at baseline, 4 times/day for 1 week in treatment week 3, and 4 times/day for 1 week in treatment week 5 | Self-report measure of momentary transdiagnostic repetitive negative thinking. Score range from 6 to 42 and higher scores indicate more severe repetitive negative thinking. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Circadian melatonin phase | At baseline and post-treatment (after 5 weeks of treament) | Dim light melatonin onset assessed by taking hourly saliva samples in dim light conditions for 10 hours beginning 7 hours before typical bedtime and ending 2 hours after typical bedtime. |
Countries
United States
Contacts
CONTACTRebecca Cox, BA
PRINCIPAL_INVESTIGATORRebecca Cox, PhD
Washington University School of Medicine
Outcome results
None listed