Meningeal Metastasis, Non-Small Cell Lung Cancer
Conditions
Keywords
Non-Small Cell Lung Cancer, meningeal metastasis, real-world study, database
Brief summary
This is a retrospective and prospective study planned to include NSCLC patients with Leptomeningeal metastasis (LM) and treated with antitumor therapy after 2018, from multiple centers such as the First Affiliated Hospital of Guangzhou Medical University, Guangdong Sanjiu Brain Hospital, etc., aiming to establish a database related to the treatment strategies of LM patients, and to evaluate the efficacy (eg. Overall Survival/Time to Failure) and safety of different treatment strategies of LM patients, etc., as well as the significance of concomitant testing in LM patients.
Detailed description
retrospective and prospective study
Interventions
OTHERNot applicable- observational study
This is a retrospective and observational study. Not Applicable
Sponsors
Guangzhou Medical University
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* non-small cell lung cancer patients with Leptomeningeal metastases diagnosed after January 2018; * Patients who underwent antitumor therapy after diagnosis of LM.
Exclusion criteria
* Patients with small cell lung cancer components; * complicated with tumors other than non-small cell lung cancer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival(OS) | 6 years |
Secondary
| Measure | Time frame |
|---|---|
| Time to failure(TTF) | 6 years |
| Change in cerebrospinal fluid and metabolic markers during treatment | 6 years |
| Safety during actual clinical treatment | 6 years |
Countries
China
Contacts
Primary Contacthong hai Yang
Outcome results
None listed