HIP AND KNEE OSTEOARTHRITIS, Geriatric Assessment, Geriatric Depression
Conditions
Keywords
procaine, infiltration, geriatric assessment, periarticular injections, gerovital h3, geriatric depression, hip osteoarthritis, knee osteoarthritis, ana aslan, physical therapy, activities of daily living (ADL), instrumental activities of daily living (IADL)
Brief summary
§ The goal of this clinical trial is to assess the effect of periarticular procaine injections combined with physical therapy on joint pain in individuals 65 and older suffering from osteoarthritis of the hip or the knee. The main question it aims to answer is: Is procaine effective in decreasing joint pain? Researchers will compare procaine injections combined with physical therapy to physical therapy only to evaluate whether or not procaine helps decrease joint pain. Participants will: Undergo procaine periarticular injections and physical therapy Assess their symptoms and pain using scales and tests provided
Detailed description
This clinical trial aims to evaluate the safety and efficacy of procaine complex injections in managing pain and improving functional capacity in elderly patients with osteoarthritis in the knee and/or hip. The study enrolled 178 patients aged 65 and older, who were randomly assigned to receive either physical therapy combined with periarticular procaine injections or physical therapy alone. Pain levels were assessed using the Visual Analogue Scale (VAS), and functional capacity was evaluated using the Lequesne Index, Activities of Daily Living (ADL), Instrumental Activities of Daily Living (IADL), and other geriatric assessment tools. Results indicated significant pain reduction and functional improvement in the procaine group, highlighting a safe alternative treatment to surgery for older adults with osteoarthritis.
Interventions
DRUGPeriarticular Procaine Injection (PAPI)
Participants will receive periarticular 5 ml procaine injections targeting painful joints for 10 consecutive days alternating between knee- and/or hip joints
OTHERKinesiotherapy
Kinesiotherapy
Sponsors
Sf Luca Chronic Disease Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Intervention model description
Participants are divided into an experimental group that receives the basic treatment combined with the intervention and one control group that receives the basic treatment
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults aged 65 and older diagnosed with knee or hip osteoarthritis per the American College of Rheumatology criteria. Must exhibit radiographic evidence of OA and experience persistent joint pain
Exclusion criteria
* Individuals with Alzheimer's, severe depression, cancer, or other severe health conditions, and those with allergies to procaine
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain Levels | Baseline to Day 10 | Change in Pain Level on Visual Analogue Scale (VAS) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Functional Improvement | Baseline to Day 10 | Change in Lequesne Index Score |
| ADL and IADL Scores | Baseline to Day 10 | Changes in Activities of Daily Living and Instrumental ADL scores |
| Geriatric Depression Scale | Baseline to Day 10 | Change in Depression Symptoms |
Countries
Romania
Outcome results
None listed