Head and Neck Cancer, Healthy
Conditions
Keywords
MSOT, Head and neck cancer, healthy, flap surgery, graft, perfusion, oxygenation
Brief summary
Multispectral Optoacoustic Tomography (MSOT) is a promising imaging technology that utilizes pulsed laser light. One of the key capabilities of this technology is measuring oxygenation within human tissue. This proposed study aims to investigate possible limitations of human tissue used for reconstructive surgery due to flawed tissue perfusion. Healthy volunteers as well as patients with a diagnosed head and neck cancer entity will be recruited. Both cohorts will then be scanned on different body areas (most common tissue sites used for reconstructive surgery on the back, arms and legs) to assess differences in muscle oxygenation between the healthy and tumor patient cohort using MSOT. The hypothesis of the study is, that patients with diagnosed head and neck cancer entities are prone to compromised tissue perfusion due to a high prevalence of smoking within the head neck tumor patient cohort and therefore perfusion restirciting diseases e.g. peripheral arterial occlusive disease (PAOD).
Interventions
Non-invasive transcutaneous MSOT imaging of muscle and subcutaneos regions.
Sponsors
University of Erlangen-Nürnberg Medical School
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Cohort 1: Histopathological diagnosed head and neck tumor patients. * Cohort 2: Healthy adults.
Exclusion criteria
* Pregnancy / breastfeeding * ink / tattoo in the areas of interest (upper back, distal forearm, upper and lower leg) * missing consent form * Cohort 2: Chronical abuse of alcohol and nicotine.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle oxygenation (in arbitrary units) | Immediately before and after intervention (exercise) within both cohorts. Within the cohort of head and neck tumor patients, possible postoperative second measurement of the transplanted tissue after performed reconstructive surgery. | Oxygenated hemoglobin signal in the measured muscle regions in all different cohorts. |
| Quantitative hemoglobin-associated signal (in arbitrary units) | Immediately before and after intervention (exercise) within both cohorts. Within the cohort of head and neck tumor patients, possible postoperative second measurement of the transplanted tissue after performed reconstructive surgery. | Hemoglobin signal in the measured muscle regions in all different cohorts. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative compromise of microvascular free flaps (Microvascular revision, flap failure) | Postoperative observation of the free flap within the stationary visit until dismission (14 days) | Correlation between preoperative accquired MSOT parameters (e.g. quantitative hemoglobin-associated signal, muscle oxygenation, oxygen saturation) in the head and neck cancer cohort and the clinical outcome of the reconstructive surgery (Microvascular revision, flap failure). |
| Oxygen saturation (in %) | Immediately before and after intervention (exercise) within both cohorts. Within the cohort of head and neck tumor patients, possible postoperative second measurement of the transplanted tissue after performed reconstructive surgery. | Proportion of oxygenated hemoglobin signal compared with total hemoglobin signal in the measured muscle regions in all different cohorts |
| Questionnaire items (Age, sex, height, weight, BMI, skin type, pre-existing conditions, medication, substance abuse [alcohol, nicotine], moderate physical activity per week) | Once at the date of inclusion for the study. | Questionnaire items for both the healthy and the head and neck tumor cohort. |
| Muscle oxygenation (in arbitrary units) | Immediately before and after intervention (exercise) within both cohorts. Within the cohort of head and neck tumor patients, possible postoperative second measurement of the transplanted tissue after performed reconstructive surgery. | Oxygenated hemoglobin signal in the measured muscle regions in all different cohorts. |
Countries
Germany
Contacts
Primary ContactFelix Wachter
Backup ContactJonas Wolf, Dr. med.
Outcome results
None listed