ROX Index Versus MROX Index to Predict Treatment Outcome for High Flow Nasal Cannula And/or Noninvasive Ventilation in Patients with Respiratory Failure

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06715644

Enrollment

120

Registered

2024-12-04

Start date

2025-01-01

Completion date

2027-02-01

Last updated

2024-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Failure

Keywords

ROX index, mROX index, high flow nasal cannula, noninvasive ventilation

Brief summary

One of managing steps in respiratory failure is high flow nasal cannula (HFNC), but the exact time to turn to invasive machine ventilation (IMV) is necessarily being determined. Respiratory rate and oxygenation (ROX) index, defined as the ratio of oxygen saturation as measured by pulse oximetry (SO2)/ FiO2 to respiratory rate (RR), is used to determine when to intubate the patients who are on HFNC and prevent the delayed intubation. Modified Respiratory rate and oxygenation (mROX), defined as (PaO2/ FiO2) / respiratory rate, is also used to point the time of intubation in case HFNC of patients with respiratory failure . The diagnostic and prognostic accuracy of both parameters are reported in previous papers, but the preference of them is under research. In this study, we aim to observe and compare the diagnostic accuracy between ROX and mROX in determine the time of invasive mechanical ventilation.

Detailed description

Respiratory Failure (RF) is a condition where there's insufficient oxygenation in the body tissue, whether acute, chronic or acute on chronic; occurring due to decreased oxygen or excessive carbon-dioxide in the blood . There are four types of respiratory failure; Hypoxemic respiratory failure (Type1), hypercapnic respiratory failure (Type2), ) . Causes of RF are varied and accounted for any abnormality related upper respiratory tract, lower respiratory tract, central and peripheral nervous system or muscles of respiration . However, in the last three decades, the most common causes of RF is acute myocardial infarction (AMI), acute respiratory distress syndrome (ARDS), RF related to corona virus (Covid-19) and acute exacerbation of chronic obstructive lung disease (COPD).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Adult patients of both sex aged between 18 to 80 years * Patient diagnosed with acute type 1or 2 or chronic type 1or 2 respiratory failure. * Patient for chest ICU admission * Patient for HFNC and/ or Noninvasive mechanical ventilation.

Exclusion criteria

* Pediatric patients * Pregnant females * Patients who are for intubation on ICU admissionc.

Design outcomes

Primary

Measure	Time frame	Description
diagnostic accuracy of ROX in determine the time of invasive mechanical ventilation.	baseline	Sensitivity and Specificity in determine the time of invasive mechanical ventilation.

Secondary

Measure	Time frame	Description
diagnostic accuracy mROX index in determine the time of invasive mechanical ventilation.	baseline	Sensitivity and Specificity of mROX index in determine the time of invasive mechanical ventilation.

Contacts

Primary ContactEsraa Ramadan Abd el rahman Ibraheim, resident doctor

rmdanasra024@gmail.com+201032164070

Outcome results