PREdiction of succeSSful weanING From Continuous Renal Replacement Theraphy: the Possible Role of Delta C-cistatin

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06714214

Acronym

PRESSING

Enrollment

152

Registered

2024-12-03

Start date

2024-10-01

Completion date

2026-11-30

Last updated

2024-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury

Keywords

C cistatin, acute kidney injury, CRRT, weaning

Brief summary

The goal of this observational study is to know if, in patients with acute kidney injury, naive for renal injurie, admitted to different ICUs, the change in plasma concentration of c-cistatin, between initiation and discontinuation of CRRT, is a predictive finding to optimize the withdrawal time of renal support

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* age ≥ 18 years; * diagnosis of acute kidney injury (defined according to KDIGO 2012 criteria) * need for support with CRRT according to the indications of the nephrologist consultants and Clinical Practice * Obtaining informed consent

Exclusion criteria

* CRRT already ongoing (in another department not participating in the study) at the time of transfer/admission to intensive care; * need for RRT (any type and modality) in the 14 days prior to enrolment; * diagnosis of AKD/CKD/ESRF on admission; * Discontinuation of CRRT under conditions that do not comply with the criteria established by the study; * Need for CRRT not associated with AKI condition (e.g. elimination of toxicants); * pregnant women; * presence of known thyreopathy * Continuous use of corticosteroids * patient with known neoplastic disease.

Design outcomes

Primary

Measure	Time frame	Description
the change in plasma concentration of c-cistatin between initiation and discontinuation of CRRT is a predictive finding in patients with acute kidney injury admitted to the ICU	From enrlollment to the weaning from CRRT and 14 days after	To verify whether the change in plasma concentration of c-cistatin between initiation and discontinuation of CRRT is a predictive finding in patients with acute kidney injury admitted to the ICU It is measured as (cistatin at weaning minus cistatin basal) divided by cistatine basal, in percentage

Countries

Italy

Contacts

Primary ContactFrancesco Marino, MD

francesco.marino@aosp.bo.it3293842166

Outcome results