Rapid Non-Invasive Brain Stimulation for Hoarding Disorder

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06712914

Acronym

TMS-HOLA

Enrollment

Registered

2024-12-02

Start date

2026-03-27

Completion date

2028-01-01

Last updated

2026-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Clutter, Hoarding, Hoarding Disorder

Keywords

TMS, hoarding disorder, hoarding, clutter, iTBS

Brief summary

This study explores whether rapid non-invasive brain stimulation can help reduce hoarding disorder symptoms.

Detailed description

Hoarding disorder (HD) is characterized by difficulty letting go of possessions, leading to clutter that congests living spaces and impairs daily functioning. The majority of HD patients treated with cognitive behavioral therapy for HD usually experience considerable residual symptoms. New treatments are greatly needed. This study explores whether rapid non-invasive brain stimulation can help reduce hoarding disorder symptoms.

Interventions

DEVICEMagPro X100 by MagVenture

Participants will receive 5 session per day of TBS for 6 days (30 sessions total). Six treatment days have to occur within a 2 week period. Each session will be comprised of 1800 pulses, using a MagVenture MagPro X100.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

1. Age 18-70 years 2. Primary diagnosis of hoarding disorder 3. Sufficient severity of hoarding symptoms 4. Willing and able to understand and complete consent and study procedures

Exclusion criteria

1. Psychiatric or medical conditions or medications that make participation unsafe 2. Pregnant or nursing females 3. Previous exposure to TMS or ECT 4. History of any implanted device or psychosurgery

Design outcomes

Primary

Measure	Time frame	Description
Change in Compulsive Acquisition Scale (CAS)	Change from baseline to 3 weeks after treatment starts	The Compulsive Acquisition Scale (CAS) is an 18-item questionnaire that measures the extent to which individuals acquire and feel compelled to acquire possessions. The total score (sum of 18 items) ranges from 0 to 126. Total score higher than 48 shows significant difficulty with acquiring.

Countries

United States

Contacts

CONTACTPaula Munoz Rodriguez, PhD

clutterhelp@stanford.edu650-723-4095

PRINCIPAL_INVESTIGATORCarolyn I Rodriguez, MD, PhD

Stanford University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 23, 2026