Biomarkers in EV Associated With Marrow Adiposity in Anorexia

Identification of Biomarkers in Extracellular Vesicles Associated With Marrow Adiposity and Bone Deterioration Caused by Nutritional Deficiencies

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06712485

Acronym

VE_BMAT_AN

Enrollment

Registered

2024-12-02

Start date

2025-05-15

Completion date

2026-07-31

Last updated

2025-05-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anorexia Nervosa (DSM-IV Revised Criteria), Anorexia Nervosa Restricting Type

Keywords

Extracellular Vesicles, Bone Deterioration, Biomarkers, Bone Marrow Adipose Tissue, Nutritional Deficiencies

Brief summary

The aim of this observational study is to identify biomarkers in extracellular vesicles associated with medullary adiposity occurring in patients with anorexia nervosa. The main question it aims to answer is: Can this medullary adiposity be associated with the bone deterioration observed in this population? Participants will be assessed for body composition and a blood sample will be taken by non-invasive techniques.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

For AN group: * Diagnosis of active AN according to DSM-5 criteria * BMI of less than 17kg/m2 * Present amenorrhoea in the 3 months prior to the start of the study. For AN-R group: * Achieved weight gain of more than 85%. * Normal menstruation in the last 3 months. For Control group: * Population of the same age and gender as the AN and AN-R groups. * If pubertal population, presenting a chronological age of ± 2 years. * Normal menstruation * Normal BMI (\>18.5 kg/m2) * No presence of previous dietary transtrons.

Exclusion criteria

* Not receiving oestrogens, contraceptives or glucocorticoids in the 3 months prior to the start of the study. * Not to suffer from chronic diseases, such as diabetes, pathologies affecting the bone system or thyroid function. * Do not take calcium or vitamin supplements.

Design outcomes

Primary

Measure	Time frame	Description
Biomarkers related to medullary adiposity	1 day	Blood samples to isolate extracellular vesicles for omics studies

Secondary

Measure	Time frame	Description
Bone Mineral Density	1 day	Bone mineral density measured by densitometry
Body Composition	1 day	Fat and muscle mass measured by ultrasound

Countries

Spain

Contacts

Primary ContactMarta Camacho-Cardenosa, pHd

marta.camacho@imibic.org+34 957213814

Outcome results