Multiple Sclerosis
Conditions
Keywords
Multiple Sclerosis, exercise, function, upper extremity, neuromuscular exercise training, manual dexterity
Brief summary
The effectiveness of upper extremity focused neuromuscular exercise training in early stage people with MS will be investigated. People with MS enrolled in the study will be randomly assigned to three groups: Neuromuscular Exercise Group (NEG), Conventional Exercise Group (CEG), and Control Group (CG). All three groups will be assessed with primary and secondary outcome measures at baseline, week 8, and week 12. NEG, CEG, and CG will be initially assessed for upper extremity function, cognitive function, lower extremity function, grip strength, proximal muscle strength, sensation, coordination, fatigue, postural sway, and core muscle strength and endurance. Then, NEG will receive clinically supervised upper extremity focused neuromuscular exercise training with a minimum of 60 minutes of session time, 2 days a week for 8 weeks. This exercise training includes steps for postural control, weight transfer, proximal and distal muscle strengthening, proprioception, coordination and reaction speed. Similarly, CEG will receive clinically supervised traditional upper extremity exercise training, twice a week for 8 weeks, with a minimum of 60 minutes of session time. This exercise training includes strengthening with the band and manuel dexterity exercises. In both groups, stretching and mobility exercises will be added to the warm-up and cool-down exercises before and after the program. During this process, CG will be on the waiting list. At the end of 8 weeks, all three groups will be re-evaluated. After the exercise training, follow-up will be done and evaluations will be repeated in the 12th week. This study will provide evidence on the effects of upper extremity-focused neuromuscular exercise training on physical and cognitive functions in early-stage people with MS compared to traditional treatment approaches.
Interventions
This group will receive neuromuscular exercise training with 60-75 minute sessions per day, 2 days a week, for 8 weeks. Warm-up Program - 5 minutes Postural Control-Weight Transfer - 10-15 minutes Strength Training - 30-35 minutes Proprioception - Coordination - Reaction Speed 10-15 minutes Cool-down Program - 5 minutes
This group will be given traditional strength exercise training consisting of 60-75 minute sessions per day, 2 days per week for 8 weeks. Warm-up Program - 5 minutes Strength Training - 30-35 minutes Manuel Dexterity - 15-20 minutes Cool-down Program - 5 minutes
Sponsors
Istanbul Aydın University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 64 Years
Healthy volunteers
No
Inclusion criteria
* Definite MS according to McDonald criteria, * 18-64 years * RRMS, * EDSS \< 4, * Minimal or moderate upper extremity involvement
Exclusion criteria
* Having an attack in the last three months, * Mini Mental Test \<24 or visual deficit, * Other medical conditions accompanying MS (cardiac, orthopedic or rheumatic, etc.), * Being pregnant or breastfeeding, * Doing regular exercise - receiving physiotherapy, * Having spasticity of 2 or more in the upper extremity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hand Dynamometer | At the beginning, at the end of 8 weeks and 12 weeks | To assess hand grip strength |
| Nine Hole Peg Test | At the beginning, at the end of 8 weeks and 12 weeks | To assess unilateral function of the upper extremity |
| Minnesota Manual Dexterity Test | At the beginning, at the end of 8 weeks and 12 weeks | To assess bilateral upper extremity function |
| Manual Ability Measure-36 | At the beginning, at the end of 8 weeks and 12 weeks | To assess upper extremity function. A higher score indicates better hand function. |
| Timed 25-Foot Walk | At the beginning, at the end of 8 weeks and 12 weeks | To assess lower extremity function |
| Symbol Digit Modalities Test | At the beginning, at the end of 8 weeks and 12 weeks | To assess cognitive function |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hand Held Dynamometer | At the beginning, at the end of 8 weeks and 12 weeks | To assess elbow muscle strength |
| Biodex Balance System | At the beginning, at the end of 8 weeks and 12 weeks | To assess postural sway |
| Laser-pointer Assisted Angle Reproduction Test | At the beginning, at the end of 8 weeks and 12 weeks | To assess of shoulder proprioception |
| Finger Tapping Test | At the beginning, at the end of 8 weeks and 12 weeks | To assess upper extremity coordination |
| Fatigue Severity Scale | At the beginning, at the end of 8 weeks and 12 weeks | To assess fatigue severity. A high score indicates high fatigue severity. |
| Plank | At the beginning, at the end of 8 weeks and 12 weeks | To assess core muscle endurance |
| Curl-up | At the beginning, at the end of 8 weeks and 12 weeks | To assess core muscle strength |
Contacts
Primary ContactUğur Ovacık
Outcome results
None listed