Osteoarticular Infections
Conditions
Brief summary
The study aims to optimize individualized treatment of anti-infective drugs in osteoarticular infections by analyzing drug exposure in patients blood and/or tissues using population pharmacokinetics.
Interventions
Anti-infective drugs are administered using the traditional clinical dosing regimen, with no interventions.
Sponsors
Shandong University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients with suspected/confirmed osteoarticular infections who are undergoing anti-infective drug therapy.
Exclusion criteria
* Pregnant/lactating women. * There are other factors that the researchers think are not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clearance (L/h) | Through study completion, an average of 30 days |
| Volume of Distribution (L) | Through study completion, an average of 30 days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| ratio of the area under the concentration-time curve from 0 to 24 hours | Through study completion, an average of 30 days | For time-dependent antimicrobials, the PD target is defined as the time of free drug concentration beyond MIC during the dose interval. For concentration-dependent antimicrobials, the PD target is defined as the ratio of the area under the concentration-time curve from 0 to 24 hours to the MIC. |
| erythrocyte sedimentation rate | Through study completion, an average of 30 days | Clinical treatment outcome |
| Adverse events | Through study completion, an average of 30 days | — |
Countries
China
Contacts
Primary ContactWei Zhao, Ph.D
Outcome results
None listed