Predicting If the Blood Pressure Will Drop After Spinal Anesthesia Using Ultrasound of the Neck

Prediction of Hypotension After Spinal Anesthesia by Doppler Measurement of the Corrected Carotid Flow Time and the Peak Velocity Variation Within the Common Carotid Artery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06711289

Enrollment

Registered

2024-12-02

Start date

2023-04-12

Completion date

2023-09-29

Last updated

2024-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal Anesthesia-induced Hypotension

Keywords

Spinal anesthesia-induced hypotension, Carotid Doppler ultrasound, Common carotid artery, Corrected carotid flow time, Peak velocity variation

Brief summary

After a spinal injection, blood pressure might drop for a short time, similar to what happens with general anesthesia. This drop can be different for each person. An anesthesiologist will use medicine to bring the blood pressure back to normal. If this drop could be predicted in advance, it would help the anesthesiologist treat it faster, making the procedure even safer and preventing side effects like dizziness or nausea.

Interventions

DIAGNOSTIC_TESTCarotid ultrasound measurement

Pulsed-wave Doppler acquisition of the carotid artery. One acquisition will be made with the slow-speed setting (33 mm/s) and one with the medium-speed setting (66 mm/s).

DIAGNOSTIC_TESTVital sign measurement

Measurement of noninvasive blood pressure, at different time points before and after the induction of spinal anesthesia.

DRUGSpinal anesthesia

Following the standard of care, the patients received spinal anesthesia. The type and dosage of the local anesthetic were at the discretion of the treating anesthesiologist.

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adult patients of either sex who are scheduled for elective surgery under spinal anesthesia, * Who fasted for 6 hours or more

Exclusion criteria

* Age \<18 years old * No informed consent for study participation * Contra-indication for spinal anesthesia * Emergency surgery * Known poor left or right ventricular function / heart failure * Moderate to severe valvular disease * Atrial fibrillation * Pacemaker rhythm * Carotid artery stenosis \> 50% * History of cerebrovascular accident (CVA) or transient ischemic attack (TIA) * History of cerebral trauma * Pregnancy * Neck complaints * Morbid obesity (BMI \> 40 kg/m2)

Design outcomes

Primary

Measure	Time frame	Description
Determine the predictive value of pre-anesthetic carotid parameters to predict spinal anesthesia-induced hypotension.	Prior to surgery.	To determine the predictive value of pre-anesthetic corrected carotid flow time (ccFT) and peak velocity variation values for hypotension after induction of spinal anesthesia.

Secondary

Measure	Time frame	Description
Correlation between carotid parameters and blood pressure.	Trough study completion, an average of 30 minutes.	To determine the correlation between the pre-anesthetic corrected carotid flow time (ccFT) and peak velocity variation on one hand and the maximal changes in systolic and mean arterial blood pressure after spinal anesthesia on the other hand.

Other

Measure	Time frame	Description
Intra-observer and inter-observer reproducibility of carotid Doppler parameters.	Prior to surgery.	To determine the intra-observer and inter-observer reproducibility of Doppler parameters derived by two experienced sonographers.

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 5, 2026