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Repeated Injection of I PRF and Autogenous Bone Graft for Alveolar Ridge Augmentation

Repeated Injection of I PRF and Autogenous Bone Graft for Alveolar Ridge Augmentation :randomized Controlled Clinical Trial

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06711250
Acronym
I-PRF
Enrollment
28
Registered
2024-12-02
Start date
2024-04-01
Completion date
2024-11-01
Last updated
2024-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alveolar Bone Loss, Alveolar Ridge Abnormality

Keywords

A lveolar ridge defect , Khoury technique Guided bone regeneration, i PRF, CBCT analysis

Brief summary

The current st udy's objective was to validate the repeated effect of i PRF with autogenous bone on the of gingival thickness , width a n d volumetric bone changes durig maxillary alveolar augmentation using cone beam computer tomography (CBCT). Patients and methods:

Detailed description

The study was a randomized clinical study in which participants needed to augment defective ridge were selected from the Outpatient Clinic, Department of Oral Medicine, Periodontology and Diagnosis , Faculty of Dental Medicine for Girls, Al Azhar University. The Research Ethics Committee, Faculty of Dental Medicine for Girls, Al Azhar University (REC code (P. PD 24 19 ) certified this study and a signed informed consent form with approval was obtained from each. Each patient who was enrolled in the study had a complete medical record and a proper clinical examination. These patients had to have a horizontal or vertical alveolar ridge deficiency and have enough bone in the mandibular donor site (external oblique ridge). However, patients showing any signs of active periodontal disease, on long term corticosteroid therapy, persons taking bone metabolism drugs as well as individuals suffering from any systemic illness that may impact bone repair were excluded from the study. Patients were assigned to one of two 2 groups, group I or group II. Group I, consisted of patients grafted with autogenous bone graft alone. I n Group II, patients were grafted using autogenous bone combined with repeated injection of i PRF Assessment of the alveolar ridge dimension and the bone block to be harvested preoperatively using CBCT. T he measurements of the alveolar ridge mesio distaly and bucco lingually in mm were determined at the recipient site . It was crucial to visualize the anatomic structures at the osteotomy site, including the alveolar canal, the mental foramina, and the teeth roots present to create ideal bone cutting planes according to the depth and extension of the graft without any injuries to the aforementioned structures.

Interventions

autogenous bone augmentation

PROCEDUREkhoury technique with i-PRF injections

autogenous bone augmentation with repeated i-PRF injections

Sponsors

Ain Shams University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
Yes

Inclusion criteria

* patients who have a horizontal or vertical alveolar ridge deficiency

Exclusion criteria

* patients showing any signs of active periodontal disease * patients on long term corticosteroid therapy, * patients taking bone metabolism drugs * patients suffering from any systemic illness that may impact bone repair

Design outcomes

Primary

MeasureTime frameDescription
width of the alveolar ridgebaseline, 6 months & 9 monthsCBCT will be used to assess the width of the alveolar ridge

Secondary

MeasureTime frameDescription
volumetric analysis of boneat baseline, 6 and 9 monthsvolumetric analysis ob bone using CBCT to assess the bone volume

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026