Acute Kidney Injury, Pediatric Cardiac Surgery
Conditions
Brief summary
The study aims to evaluate whether preoperative albumin supplementation in pediatric patients with hypoalbuminemia undergoing cardiac surgery can reduce inflammatory responses and prevent acute kidney injury (AKI) following cardiopulmonary bypass.
Interventions
DRUGAlbumin solution
A 20% albumin solution is administered over one hour starting from the induction of anesthesia, using the following formula: (4.0-preoperative serum albumin (g/dL))×plasma volume (kg×0.65-0.8 dL)
The same volume of crystalloid solution as the administered albumin is infused.
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
No minimum to 7 Years
Healthy volunteers
No
Inclusion criteria
* Pediatric patients under 7 years of age undergoing cardiac surgery with cardiopulmonary bypass * Preoperative serum albumin level of 4.0 g/dL or lower
Exclusion criteria
* abnormal preoperative creatinine level * history of dialysis * liver dysfunction * diabetes * history of hypersensitivity to albumin * coagulation disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| incidence of acute kidney injury (AKI) | assessed up to postoperative day 7 | The difference in the incidence of acute kidney injury (AKI) between groups, as measured by the KDIGO criteria |
Countries
South Korea
Contacts
Primary ContactJi-Hyun Lee
Outcome results
None listed