Tuberculosis
Conditions
Keywords
HIV, immunocompromised, cytokines
Brief summary
Tuberculosis (TB) is caused by Mycobacterium tuberculosis and is one of the top 10 causes of mortality worldwide. It is estimated that in 2017, 10 million people were infected with TB, and 1.6 million died from the disease, including 0.3 million people with human immunodeficiency virus (HIV) infection . TB remains the primary killer of HIV-positive individuals. TB incidence is falling at about 2% per year . Airborne transmission of M. tuberculosis typically causes TB infection in both immunocompetent and immunocompromised hosts and the disease is symptomatic and contagious .
Detailed description
TB and HIV infections are strictly linked together. TB is the most common opportunistic infection and causes high morbidity rate among people living with HIV. Because of the decrease in cell-mediated immunity, HIV alters the pathogenesis of TB, thereby expressively increasing the risk of TB in HIV-positive patients and eventually leading to more severe complications and forms of TB.
Interventions
DIAGNOSTIC_TESTP24 antigens and antibody
estimation of antigens and antibodies to diagnose HIV
DIAGNOSTIC_TESTzeihl - Nelsen stain
staining sputum from patients with HIV to detect tubercle bacilli
DIAGNOSTIC_TESTculture on Lowenstein jensen media
spenciem will be inoculated on LJ media and kept for 2-8 weeks, to see small white colonies
DIAGNOSTIC_TESTMolecular detection of antibiotic resistance
to see the pattern of antibiotic resistance of tubercle bacilli
Sponsors
Sohag University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Patients with chronic chest disease
Exclusion criteria
* Patients with other respiratory or infectious diseases.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The Prevalance of tubercuolsis in immunocompetent patients suffereing from chronic chest problems | December 2024- June 2025 | Patients suffering from chronic chest problems will be screened for presence of TB bacilli using chest X-ray, sputum smear, culture on LJ media, detection of DNA of TB bacilli using PCR |
| The prevalence of tuberculosis in HIV patients | December 2024- June 2025 | Detection of tubercle bacilli in HIV positive patients , these patients will be screened for presence of TB bacilli using chest X-ray, sputum smear, culture on LJ media, detection of DNA of TB bacilli using PCR |
Countries
Egypt
Contacts
Primary ContactNoha S Shafik, Lecturer
Backup ContactMona Lecturer
Outcome results
None listed