Clinical, Neurophysiological Assessment, Open Heart Surgery, Postoperative
Conditions
Brief summary
This study aims to investigate postoperative clinical, cognitive and neurophysiological assessment of patients after open heart surgery among sample of Egyptian patients.
Detailed description
Coronary artery bypass grafting (CABAG) is one of the most common major surgical procedures, as more than 800,000 patients worldwide undergo myocardial revascularization procedures every year. Cardiopulmonary bypass (CPB) is an extracorporeal circulation procedure that assists the operation of cardiac and great vessels and is associated with perioperative morbidity and mortality. Preoperative neurophysiological status as measured by electroencephalogram (EEG) had a specificity of 94.7% and a sensitivity of 76.9% for predicting 1-week postoperative cognitive status and with specificity of 78.3% and a sensitivity of 77.8% for predicting 3-months postoperative cognitive status.
Interventions
DEVICEDigital Electroencephalography (DEEG)
The enrolled patients will undergo Digital Electroencephalography (DEEG) monitoring for at least two hours. A senior epileptologist will make a DEEG interpretation to detect DEEG abnormality. DEEG patterns will be categorized according to the American Clinical Neurophysiology Society's standardized critical care DEEG terminology(normal, slowing and asymmetry, sharp and wave, periodic discharges, ictal patterns burst suppression, and electrocerebral silence)
Sponsors
Ain Shams University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient ≥ 60 years. * Both sexes. * Patients who are scheduled for on-pump open heart surgery either isolated coronary artery bypass grafting (CABG) or combined CABG and valve surgery.
Exclusion criteria
* Patients with a past history of CNS disease (e.g. Epilepsy, brain tumors, or Dementia). * Patients with metabolic disturbance. * Illiterate patient. * Patient with sever cognitive impairment on Mini-mental state Examination (MMSE) and/or Montreal Cognitive Assessment (MoCA) * Patients who cannot undergo DEEG recordings (eg, uncooperative). * Patients with abnormal brain images except for small vessel disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neurological complications | 4 months postoperatively | Neurological complications, including nonconvulsive seizures after open heart surgery, will be recorded. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Electroencephalography (DEEG) monitoring | 24 hours postoperatively | The enrolled patients will undergo Digital Electroencephalography (DEEG) monitoring for at least two hours. A senior epileptologist will interpret the DEEG to detect abnormalities. The DEEG patterns will be categorized according to the American Clinical Neurophysiology Society's standardized critical care DEEG terminology(normal, slowing and asymmetry, sharp and wave, periodic discharges, ictal patterns burst suppression, and electrocerebral silence). |
Countries
Egypt
Contacts
Primary ContactOsama A Ebrahim, Master
Outcome results
None listed