Role of MDCT in Grading of Esophageal Varices

The Role of Multidetector Computed Tomography(MDCT) in Grading of Oesophageal Varices in Cirrhotic Patients in Comparison to Endoscopy

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06707298

Enrollment

Registered

2024-11-27

Start date

2024-12-31

Completion date

2026-01-31

Last updated

2024-11-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

MDCT Esoghageal Varices

Keywords

MDCT, Esophageal varices

Brief summary

Esophageal varices are one of the major complications of liver cirrhosis.Accurate grading of these varices is essential for effective management . Traditionally, esophagogastroduodenoscopy is the gold standard for diagnosing and grading esophageal varices,Multi detector computed tomography (MDCT) has emerged as a non-invasive alternative for evaluating esophageal varices.it particularly appealing for patients who contraindicated to endoscopy .

Detailed description

Esophageal varices are one of the major complications of liver cirrhosis, with an estimated prevalence of approximately 80% with decompensated patients and 50% in compensated cirrhosis, pose a significant risk of life-threatening of bleeding due to portal hypertension. Accurate grading of these varices is essential for effective management . Traditionally, esophagogastroduodenoscopy (EGD) is the gold standard for diagnosing and grading esophageal varices . IT provides direct visualization, allowing for detailed assessment of variceal size and other risk factors for bleeding . However, it is an invasive procedure that requires sedation and carries some risks, such as bleeding or perforation . Multi detector computed tomography (MDCT) has emerged as a non-invasive alternative for evaluating esophageal varices. It offers detailed cross-sectional images and is widely available, providing a broader assessment of abdominal pathology. Its non-invasive nature makes it particularly appealing for patients who contraindicated to endoscopy .

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

-Cirrhotic patients with portal hypertension undergoing upper GI endoscopy.

Exclusion criteria

-Contraindication to contrast:( severe renal insufficiency, allergy to contrast agents). -Previous history of upper GI endoscopy with intervention (band ligation or sclerotherapy).- * Pregnancy. * Patients with previous transjagular intrahepatic portosystemic shunt (TIPS). * Patients with contraindication to endoscopy (severe cardiopulmonary conditions, coma unless the patient is intubated, and cardiac arrhythmias)

Design outcomes

Primary

Measure	Time frame	Description
Comparison between CT and endscopy in esophageal varices	Baseline	Agreement between MDCT and endoscopy in the grading of esophageal varices

Secondary

Measure	Time frame	Description
Assessment other complication of varicesand cirrhosis in CT	Baseline	Assessment of the presence of complications or additional findings (e.g., portal vein thrombosis,Liver pathology) and other complication related to portal hypertension as ascites or splenomegaly on MDCT.

Outcome results