The Role of Lung and Diaphragm Ultrasonography in Predicting Clinical Progression in Hypoxemic Respiratory Failure

The Role of Lung and Diaphragm Ultrasonography in Predicting Clinical Progression in Patients Receiving High-Flow Nasal Oxygen and Non-Invasive Mechanical Ventilation Support for Hypoxemic Respiratory Failure

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06706830

Enrollment

Registered

2024-11-27

Start date

2024-01-01

Completion date

2024-08-23

Last updated

2024-11-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diaphragm Ultrasonography, Hypoxemic Respiratory Failure, Lung Ultrasound

Brief summary

The goal of this observational study is to evaluate whether the risk of intubation in patients with hypoxemic respiratory failure who were monitored in the intensive care unit and received non-invasive mechanical ventilation and high-flow nasal oxygen treatment could be predicted using lung and diaphragm ultrasound. The main question it aims to answer is: Can lung and diaphragm ultrasound predict the risk of intubation in patients with hypoxemic respiratory failure?

Detailed description

Between January 1, 2024, and May 1, 2024, the diaphragm thickness fraction, excursion, LUS score, ROX index, and the LUSS/ROX index ratio were evaluated using lung and diaphragm ultrasound in 91 patients admitted to the intensive care unit with a diagnosis of hypoxemic respiratory failure. These evaluations were performed at the 6th, 12th, 24th, and 48th hours of their ICU stay, and during intubation if the decision for intubation was made

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

-PaO2 \<60 mmHg detected in arterial blood gas samples at the time of admission to the intensive care unit

Exclusion criteria

* Under the age of 18 * History of lung and diaphragm surgery * Congenital, acquired or traumatic diaphragmatic hernia * Diaphragm paralysis * Hemodynamic instability requiring vasoactive drug support * Do not agree to participate in the study

Design outcomes

Primary

Measure	Time frame	Description
Lung and diaphragm ultrasound evaluation for risk of intubation	48 hours	Lung and diaphragm ultrasound can predict risk of intubation

Secondary

Measure	Time frame	Description
ROX index evaluation for risk of intubation	48 hours	The Respiratory Rate-Oxygenation Index can predict the risk of intubation Higher score means lower risk
LUSS/ROX index ratio evaluation for risk of intubation	48 hours	LUSS/ROX index ratio can predict the risk of intubation

Countries

Turkey (Türkiye)

Outcome results