Cognitive Decline, Stroke
Conditions
Keywords
stroke, post-stroke cognitive impairment, fNIRS
Brief summary
This is an fNIRS study performed to identify biomarkers related to post-stroke cognitive impairment.
Detailed description
This was an initial screening and preliminary intervention study. Both healthy subject and stroke patients will be included in this study. Brain functional activation of each subject during the cognitive task (Stroop task, 1-back task and verbal fluency test) will be evaluated using functional near-infrared spectroscopy (fNIRS). Cognitive function related scale assessment included Mental State Examination Scale (MMSE), Montreal Cognitive Assessment (MoCA), drawing clock test (DCT), Shape trials test A.B (STT-A, STT-B), standardized digital modal test (SDMT), auditory verbal learning test-Huashan version (AVLT-H), and activity of daily living (ADL) scale will be used to evaluate the function of each patient. Biomarkers related to post-stroke cognitive impairment will be identified by by comparing differences in brain activation and brain network connectivity between patients and healthy subjects.
Interventions
None listed
Sponsors
Dingqun Bai
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
Stroke patients: 1. Diagnosis of stroke confirmed by neuroimaging (CT or MRI) 2. 18-80 years old 3. Able to complete the cognitive task 4. Able to follow instructions to complete the trial 5. Patients who signed an informed consent form. Healthy Subjects: 1. No abnormalities on cranial 2. 18-80 years old 3. Able to complete cognitive task 4. Able to follow instructions to complete the trial 5. not taking medications. 6. Subjects who signed an informed consent form.
Exclusion criteria
Stroke patients: 1. Inability to tolerate the test due to organic diseases 2. Serious mental illness that prevents them from cooperating with or tolerating the trial 3. Pregnant or lactating women 4. Had metal implants, a history of other neurological disorders, acute cardiopulmonary dysfunction. Healthy Subjects: 1. Inability to tolerate the test due to organic diseases 2. Serious mental illness that prevents them from cooperating with or tolerating the trial. 3. Pregnant or lactating women 4. Had metal implants, a history of other neurological disorders, acute cardiopulmonary dysfunction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Preliminary screening of brain function biomarkers for post-stroke cognitive impairment | 1 day | Comparison of differences in brain activation \[HbO2 (mmol/L\*mm)\] between patients with post-stroke cognitive impairment and patients without post-stroke cognitive impairment or healthy subjects |
Countries
China
Contacts
Primary ContactDingqun Bai
Backup ContactDefei Chen
Outcome results
None listed