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Assessment of Dimensional Bony Changes Following Laser Corticotomy

Assessment of Dimensional Bony Changes Following Laser Corticotomy in Rapid Canine Retraction

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06702956
Acronym
Laser
Enrollment
18
Registered
2024-11-25
Start date
2024-04-01
Completion date
2024-10-01
Last updated
2024-11-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Canine Retraction

Keywords

bony changes, laser, canine retraction, CBCT

Brief summary

The patient's bone morphology during orthodontic treatment is an important consideration. Therefore, during orthodontic tooth movement (OTM), an imbalance between bone resorption and deposition will cause the tooth to move out of the alveolar envelope . Unfavorable consequences like gingival recession and the dehiscence of an alveolar bone plate may arise from the movement of the teeth beyond the boundary of the bone they are housing. This happened because the dense cortical bone didn't enlarge to maintain protection for the moving root. On the other hand, orthodontic force creates a complex loading pattern and biological response on the periodontal ligament (PDL). there was an increase in osteoclastic activity in a compression region within the PDL. In contrast, in the other tension region, there was an increase in osteoblastic activity and mineralization of the bone matrix.

Detailed description

Orthodontic tooth movement generates complex mechanical loading patterns with corresponding complex biological responses in the periodontal tissues. This will occur only if the hard tissue around the tooth can undergo proper breakdown and build-up . The primary trigger factor responsible for orthodontic tooth movement is the strain experienced by the periodontal ligament (PDL) cells and the extracellular matrix. This strain results in alteration in the gene expression within the cells, with a production of various cytokines and chemokines, capillary vasodilatation within periodontal ligament, and migration of inflammatory cells with more cytokine production and subsequent alveolar bone remodeling in response to mechanical loading . On application of orthodontic force, the compression region within the PDL shows increased osteoclastic activity,whereas in the tension region, there is proliferation of osteoblasts and mineralization of the extracellular matrix . In general, molecules that have been linked to tensile strains and act by stimulating osteoblast progenitor cell proliferation in the periodontal ligament, with subsequent bone formation and inhibition of bone resorption similar to orthodontic tooth movement, include transforming growth factor-beta (TGF-b), various bone morphogenic proteins (BMPs), and epidermal growth factor (EGF) . On the other hand, Interleukin-1 beta (IL-1β), interleukin-6 (IL-6), CC chemokines ligand 2 (CCL2), and other inflammatory cytokines regulate osteoclastic activity through the activation of the nuclear factor kappa B (RANK) and the nuclear factor kappa B ligand (RANKL) . Corticotomy for rapid tooth movement was introduced in 1959 by Köle to cut the alveolar bone and move a tooth. He practiced corticotomy and osteotomy on various malocclusion cases. Vertically, the cortical and marrow bone between the teeth were partially removed, and either a subapical horizontal cut with alveolar bone cutting at a distance of one cm. from the apex or only a cortical osteotomy excluding the marrow bone was performed . Conventional treatment with fixed appliances likely requires an average of 1.5 to 2 years, resulting in a canine retraction rate of 0.5 to 1mm per month. Therefore, other modalities have been used to accelerate OTM such as pulsed electromagnetic field, corticotomy, dento-alveolar distraction, periodontal ligament distraction, and laser therapy Laser-based technology was a dream for oral surgery to find a new tool for bone cutting. Using of pulsed erbium-doped yttrium aluminium garnet (Er:YAG) lasers showed effective cutting tool with minimum degree of carbonization. Also, it can effectively accelerate canine retraction with no complications or discomfort for the patients. The Erbium laser affects the cortical bone, leading to RAP without postsurgical complications

Interventions

PROCEDURElaser corticotomy

stimulation of tooth movement during orthodontics treatment using Waterlase MDTM Turbo all-tissue laser therapy

PROCEDUREConventional tooth movement

tooth movement us done using wires and brackets

Sponsors

Ain Shams University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)

Intervention model description

randomized double blinded clinical trial

Eligibility

Sex/Gender
ALL
Age
15 Years to 18 Years
Healthy volunteers
Yes

Inclusion criteria

* patients who need extraction of maxillary first premolar in orthodontic treatment and patients who need canine retraction

Exclusion criteria

* medically compromised patient

Design outcomes

Primary

MeasureTime frameDescription
assessment of labial bone thickness6 monthsassessment of labial bone using CBCT

Secondary

MeasureTime frameDescription
assessment of root length6 monthsassessment of root length using CBCT

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026