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Exercise Timing on the Morning Blood Pressure Surge

The Effects of Morning vs. Evening High-intensity Interval Exercise on the Magnitude of the Morning Blood Pressure Surge

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06702930
Enrollment
31
Registered
2024-11-25
Start date
2020-01-28
Completion date
2023-06-08
Last updated
2024-11-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ambulatory Blood Pressure Monitoring, High-intensity Interval Exercise, Post-Exercise Hypotension

Keywords

Ambulatory blood pressure monitoring, Morning blood pressure surge, High-intensity interval exercise, Post-exercise hypotension

Brief summary

The goal of this clinical trial was to assess the effects of morning vs. evening high-intensity interval exercise on the magnitude of the morning blood pressure surge in young healthy adults. The main questions it aimed to answer were: * Does the timing of high-intensity interval exercise modulate the magnitude of the morning blood pressure surge? * Do sex differences exist? Participants came in and completed a bout of high-intensity interval exercise in the morning (8-10 am) and evening (5-7 pm) as well as a no exercise control, and ambulatory blood pressure was assessed for 24 hours afterwards.

Detailed description

Introductory Visit: Participants came in for 4 visits. The first visit was an introductory visit where chronotype, eligibility for exercise, and anthropometrics were measured. This was followed by a maximal incremental exercise test to determine aerobic capacity (i.e., V̇O2peak) on a cycle ergometer, and instrumentation of an ambulatory blood pressure monitor for familiarization during daily activities and sleep. Intervention Visits: Three intervention visits (control, morning exercise, and evening exercise) were completed. The order was randomized using and each visit was separated by a minimum of 36 hours. Each intervention visit began by obtaining the participant's resting blood pressure and heart rate and ended with the instrumentation of the ambulatory blood pressure monitor. No exercise was performed during the control visit. The morning exercise visit included a bout of high-intensity interval exercise between 8-10 am and the evening exercise visit included a bout of high-intensity interval exercise between 5-7 pm. The high-intensity interval exercise protocol consisted of a light intensity, 3-minute warm-up at 15% peak power followed by ten 1-minute work intervals at 80% of peak power, with each interval separated by 1-minute rest intervals at 15% peak power. A 3-minute cool down was performed at 15% peak power.

Interventions

OTHERMorning high-intensity interval exercise

High-intensity interval exercise was performed between 8-10 am

OTHEREvening high-intensity interval exercise

High-intensity interval exercise was performed between 5-7 pm

Sponsors

University of Guelph
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes

Inclusion criteria

Inclusion: * Between 18-50 years of age. * No history of known disease. * None smokers. * No use of chronic medications other than oral contraceptives. Exclusion: * \<18 years of age. * \>50 years of age. * Cardiovascular disease. * Metabolic disease. * History of smoking (within the past 3 months). * Chronic medications (other than oral contraceptives).

Design outcomes

Primary

MeasureTime frameDescription
Morning blood pressure surgeThrough study completion, an average of 4 weeks.The difference between morning blood pressure (the mean of the 4 blood pressure readings after awakening) and sleep-trough blood pressure (the mean of the lowest blood pressure during sleep and two adjacent blood pressure readings).

Secondary

MeasureTime frameDescription
Nighttime blood pressure dipThrough study completion, an average of 4 weeks.The percent difference between daytime blood pressure (average of all blood pressure readings when participants reported being awake) and nighttime blood pressure (average of all blood pressure readings when the participant reported being asleep).

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 5, 2026