Cardiopulmonary Exercise Testing in Cardiosurgery Patients

Cardiopulmonary Exercise Testing in the Prediction of Post-operative Complications in Patients Undergoing Coronary Artery Bypass Graft Surgery

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06702059

Enrollment

130

Registered

2024-11-22

Start date

2024-12-01

Completion date

2028-04-01

Last updated

2025-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Complications

Keywords

cardiovascular surgery, cardiopulmonary exercise testing, post-operative complications

Brief summary

Cardiopulmonary exercise testing (CPET) is considered to be a gold standard in pre-operative risk assessment and stratification of high risk patients scheduled for major surgery. Surprisingly, only a limited number of studies examined the prognostic role of CPET in cardiothoracic surgery. This is in contrast with rather poor discriminating quality of cardiovascular surgery risk scores and predominantly elderly cardiovascular surgery patients, with significant comorbidity and high degree of frailty. Recently, CPET was shown feasible in coronary artery bypass grafting surgery candidates. Additionally, the rest parameter, which is the partial pressure of end-tidal carbon dioxide (PETCO2) and a submaximal exercise parameter (the VE/VCO2 slope) with good prognostic utility across multiple respiratory exchange ratio values), has been shown to predict mortality and post-operative complications. Whether these rest and submaximal exercise parameters can be used to predict postoperative complications in cardiovascular surgery patients is yet to be determined.

Interventions

DIAGNOSTIC_TESTCardiopulmonary exercise testing

Subjects will undergo pre-operative cardiopulmonary exercise testing.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients scheduled for coronary artery bypass graft surgery

Exclusion criteria

* not able to perform cardiopulmonary exercise testing, off-pump revascularization, without full sternotomy, previous cardiac surgery

Design outcomes

Primary

Measure	Time frame	Description
post-operative pulmonary complications	within 30 post-operative days	pneumonia, atelectasis, respiratory failure, ARDS
post-operative cardiovascular complications	within 30 post-operative days	new arrhythmias (atrial fibrillation, supraventricular tachycardia, etc.), myocardial infarction/minimal myocardial lesion, hypotension, heart failure, pulmonary edema, pulmonary embolism, cardiopulmonary resuscitation

Secondary

Measure	Time frame	Description
Hospital and Intensive care length of stay	within 30 post-operative days	Hospital and Intensive care length of stay

Countries

Czechia

Contacts

Primary ContactIvan Cundrle, prof., M.D.

Ivan.Cundrle@fnusa.cz00420 543182553

Backup ContactMarek Lukes, M.D.

marek.lukes@cktch.cz00 420 543 182 484

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026