Cardiac Electrophysiology, Hemodynamic, Propofol, Remimazolam
Conditions
Brief summary
Brief Summary: The goal of this RCT is to compare the Safety and efficacy of remimazolam compared with propofol under EEG DSA guiding during cardiac electrophysiology studies and ablation. The main questions it aims to answer are: * Is Remimazolam as efficacy as propofol in cardiac electrophysiology studies and ablation? * Is Remimazolam lower hypotension episodes or lower vasopressor dosages compare with propofol in cardiac electrophysiology studies and ablation? If there is a comparison group: Researchers will compare \[arm information\] to see if \[insert effects\]. Researchers will compare Remimazolam to Propofol to see if Remimazolam is more feasible in cardiac electrophysiology studies and ablation. Participants will receive either Remimazolam or Propofol sedation during study period.
Interventions
DRUGPropofol
TIVA induction and maintain with Propofol.
DRUGRemimazolam
TIVA induction and maintain with Remimazolam.
DEVICEWith intubation and controlled ventilation to maintain airway
Patient receives intubation and controlled ventilation to maintain airway.
DEVICEMaintain spontaneous ventilation without intubation
Patient maintains spontaneous ventilation without intubation.
Sponsors
Taipei Veterans General Hospital, Taiwan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patient receives scheduled cardiac electrophysiology studies and ablation by the same cardiologist(one of the study investigator).
Exclusion criteria
* With existing vasopressor or shock status * Patient refusal or cannot finish Mini-Cog or QoR-15 preoperatively * Canceled by cardiologist * Allergy history to the anesthetics used in this study * History of abnormal lung function or required oxygen therapy preoperative
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hemodynamic stability--Vasopressor dosage | Introperative | Total dosage of vasopressor used during the procedure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| TIVA failure rate | Introperative | The incidence of TIVA shift to inhalation anesthetics |
| LOC time | Introperative | Time from start induction to loss of conscious |
| Emergence time | Introperative | Time from stop intravenous anesthetics infusion to eye opening |
| Sanctification of cardiologist | Perioperative | The sanctification score of the cardiologist |
| Respiratory depression require intubation | Introperative | The incidence of patients in non-intubated groups receive intubation |
| Mini-Cog | Preoperative to post-operative day 1 | The result of Mini-Cog score |
| Length of hospital stay | Upto 1 month | Length of hospital stay |
| Adverse outcome | Upto 1 month | Any adverse outcome |
| Length of CU stay | Upto 1 month | Length of CU stay |
| QoR-15 | Preoperative to post-operative day 1 | The result of QoR-15 score |
Countries
Taiwan
Outcome results
None listed