Breaking Prolonged Sitting With Physical Activity, Sedentary Behaviors
Conditions
Keywords
Sedentary behavior, sitting interruptions, cognition, glucose metabolism
Brief summary
Rationale: Sedentary behavior (SB) has been associated with impaired cognitive function in elderly, and negatively impacts glucose metabolism. Interrupting sitting with physical activity (PA) bouts may exert beneficial effects on cognitive function via an improved glucose metabolism. Nevertheless, the impact of breaking up prolonged sitting with various frequencies of PA bouts remains unexplored in young sedentary adults. Moreover, we hypothesize that the pattern of the breaks modifies the effects. Thus, randomized controlled trials (RCTs) are highly needed to investigate the effects of interrupting sitting with different frequencies of PA on cognitive function and glucose metabolism. We now hypothesize that interrupting sitting with different frequencies of walking breaks differentially affects cognitive function and glucose metabolism. Objective: The aim is to investigate the effects of breaking up sitting with different frequencies of PA bouts on cognitive function and glucose metabolism in young sedentary adults. Study design: A randomised, controlled cross-over study will be performed, consisting of four interventions in a counterbalanced order: uninterrupted prolonged sitting, short breaks, moderate breaks, and long breaks. Intervention: Participants will complete four conditions in a randomized, counterbalanced order: sitting (uninterrupted prolonged sitting without any interruptions), short breaks (walk 1 minute every 10 minutes), moderate breaks (walk 3 minutes every 30 minutes), and long breaks (walk 27 minutes during the intervention). Each condition lasts 4.5 hours.
Interventions
OTHERInterrupting sitting with walking breaks
Participants will engage in 27 minutes walking in different frequencies, including short breaks (walk 1 minute every 10 minutes), moderate breaks (walk 3 minutes every 30 minutes), and long breaks (walk 27 minutes in one time during the intervention).
Sponsors
Maastricht University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Men and women aged 18-35 years; * BMI between 18.5-24.9 kg/m2; * SB, i.e. sitting for an average of at least 9 hours per day; * Physically inactive, i.e. engaging in exercise for less than 2 to 3 times per week; * Stable body weight (weight gain or loss \< 3 kg in the past three months); * Willingness to engage in four 6-hour laboratory visits; * No difficult cannulation.
Exclusion criteria
* Not sedentary, i.e. sitting for less than an average of 9 hours per day; * Physically active, i.e. engaging in exercise for more than 3 times a week; * Abuse of drugs; * Use medication to treat BP, lipid, or glucose metabolism; * Pregnant females.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mental flexibility | baseline and 5 hours post baseline | It will be assessed using the computer-based Trial Making Test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Attention | baseline and 5 hours post baseline | Attention is assessed by the paper-based d2 attention Test |
| Glucose metabolism | baseline, 30 minutes, 1 hour, 1.5 hour, 2 hour, 3 hour, 4 hour, and 5 hour post baseline | Concentration of plasma glucose will be tested. |
| Interference | baseline and 5 hours post baseline | Interference is assessed by the computer-based Stroop task |
| Memory | baseline and 5 hours post baseline | Memory is assessed by the computer-based n-Back Test |
| Blood lipids | baseline, and 5 hours post baseline | As exploratory outcomes, concentration of serum total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C) will be tested. |
| Serum triacylglycerol (TAG) | baseline, 30 minutes, 1 hour, 1.5 hour, 2 hour, 3 hour, 4 hour, and 5 hour post baseline | As another exploratory outcome, concentration of serum TAG will be tested. |
| Mood | baseline and 5 hours post baseline | Short version of Profile of Mood States (POMS) questionnaire will be used to test mood. |
| Serum brain-derived neurotrophic factor (BDNF) | baseline, 2 hour, 3 hour, and 5 hour post baseline | Concentration of serum BDNF, as one of the exploratory outcomes will be tested. |
Countries
Netherlands
Contacts
Primary ContactRenyan Ma
Backup ContactHans Savelberg, Phd
Outcome results
None listed