Vitamin D Deficiency
Conditions
Brief summary
Clinical Comparative Evaluation of the use of Photodynamic Therapy in conjunction with the use of Vitamin D in management Stage II Grade B Periodontitis Patients: A Randomized controlled clinical trial.
Detailed description
This randomized clinical trial evaluates the effect of Photodynamic therapy alone with SRP versus Photodynamic therapy with SRP and Vitamin D regarding Clinical evaluation 1. Clinical attachment loss (CAL) 2. Probing pocket depth (PPD) 3. Bleeding on probing (BOP)
Interventions
DIETARY_SUPPLEMENTnon-surgical periodontal therapy (SRP) and Photodynamic therapy (PDT) with systemic vitamin D
non-surgical periodontal therapy (SRP) and Photodynamic therapy (PDT) with systemic vitamin D
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Systemic healthy patients * Patients aged \> 25 years * Patients suffering from stage II periodontitis with grade B were included in this study, according to 2017 world workshop classification of periodontal disease. * Patients with interdental clinical attachment loss (CAL) of 3-4 mm with radiographic evidence of bone loss extending to coronal third of the root. * Radiographic bone loss (RBL) will be diagnosed using periapical parallel technique using 6 radiographic images for full mouth (3- radiographic images for maxillary arch and 3- radiographic images for mandibular arch) including anterior, canine region and posterior teeth at baseline for diagnosis. * No history of previous periodontal therapy. * No taken medications known to interfere healing or periodontal tissue health such as anticonvulsants, calcium channel blockers, or immunosuppressant drugs. * No previous periodontal surgery at involved sites. * Good oral hygiene and good compliance with the plaque control instructions following initial therapy. * Neither taken antibiotics within the last three months nor nonsteroidal anti-inflammatory drugs within the last three months * Absence of diseases or conditions that would interfere with wound healing such as diabetes mellitus or coagulation disorders
Exclusion criteria
Patients taking Vitamin D as a nutritional supplement were excluded from the study * Smoking habits * Pregnant and lactating mothers * Patients who have been received periodontal surgery in the study area during the last 6 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical attachment level (CAL) | Day 0 - Week 6 | CAL will be measured form cemento- enamel junction (CEJ) to the depth of the pocket using UNC periodontal probe. • It will be recorded at 6 sites per tooth, the recorded readings will be used to generate mean values at each time point. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Probing Pocket Depth (PPD) | Day 0 - Week 6 | PPD will be measured form free gingival margin (FGM) to the depth of the pocket using UNC periodontal probe. |
| Bleeding on probing (BOP) | Day 0- Week 6 | Assessment after 30 seconds after gentle brushing of the sulcus with a periodontal probe, measurement quadrant |
Countries
Egypt
Contacts
PRINCIPAL_INVESTIGATORMarwa Helal
Cairo University
Outcome results
None listed