Lung Cancer Associated With Cystic Airspaces, Multiple Primary Lung Cancers, Non-Small Cell Lung Cancer
Conditions
Brief summary
The goal of this observational study is to investigate the multi-omics characterization early-stage lung cancer exhibiting distinct phenotypes including lung cancer associated with cystic airspaces, multiple primary lung cancers, and so on. The main questions it aims to answer are: * What are the differences in pathogenesis of non-small cell lung cancer with different phenotypes explored by multi-omics? * Whether differential genes lead to potential prognostic models and therapeutic targets? Participants will be followed up after surgery to answer prognosis: whether they have recurred, and the time to recurrence.
Interventions
None listed
Sponsors
Central South University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Cohort 1: Multi-omics study in early-stage synchronous multiple primary lung cancer Inclusion criteria: 1. Male or female patients:18-75 years old; 2. ECOG score:0-1; 3. Histopathologically confirmed TNM stage I-II NSCLC; 4. Considered multiple or solitary primary lung cancer by clinical criteria (Martini-Melamed criteria and ACCP criteria); 5. Good compliance, family members agree to cooperate to receive survival follow-up; 6. Understand and voluntarily sign the informed consent.
Exclusion criteria
1. A history of previous or co-existing malignant tumors; 2. Systemic anti-tumor therapies, including chemotherapy, radiotherapy, or targeted therapies (such as monoclonal antibodies, small-molecule tyrosine kinase inhibitors, among others), were administered prior to enrollment; 3. Refusal to participate in the study. Cohort 2: Multi-omics study of lung cancer associated with cystic airspaces Inclusion criteria: 1. Male or female patients:18-75 years old; 2. ECOG score:0-1; 3. Histopathologically confirmed TNM stage I-II NSCLC; 4. CT findings show solitary or multiple nodules with cystic airspaces.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immune repertoire sequencing | From enrollment to the end of surgery for 3 years |
| DNA methylome sequencing | From enrollment to the end of surgery for 3 years |
| RNA sequencing | From enrollment to the end of surgery for 3 years |
Secondary
| Measure | Time frame |
|---|---|
| Genomic sequencing | From enrollment to the end of surgery for 3 years |
| Metabolomics analysis | From enrollment to the end of surgery for 3 years |
| Radiomics analysis | From enrollment to the end of surgery for 3 years |
Countries
China
Contacts
CONTACTChen Chen
Outcome results
None listed