Colorectal Metastasis to Liver Extraction With Auxiliary Transplant and Delayed Resection

Colorectal Metastasis to Liver Extraction With Auxiliary Transplant and Delayed Resection Registry Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06698146

Acronym

CLEAR

Enrollment

Registered

2024-11-20

Start date

2025-08-27

Completion date

2035-01-01

Last updated

2026-07-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colon Cancer Liver Metastases, Colorectal Cancer Metastatic, Liver Transplant Surgery

Keywords

Liver Transplant, Colorectal Cancer Metastatic, Colorectal Cancer

Brief summary

Liver transplantation (LT) has become an accepted treatment for selected patients with unresectable liver metastases due to colorectal cancer (CRLM). The goal of this study is to look at and compare the clinical results of all the different approved methods (living vs. Deceased, whole organ vs. Split, one staged vs. Two staged) used to perform a standard liver transplant procedure for recipients with CRLM. Investigators will look at things like different procedure results, recovery in the hospital, and survival rates one year after the transplant. Investigators will also take blood samples from participants to be used in future research. All the transplant methods the investigators are comparing are standard practices approved by the United Network of Organ Sharing (UNOS).

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Inclusion: 1. All Patients of either gender ≥ 18 years of age who are listed for Liver transplant candidates at Northwestern with liver metastases due to colorectal cancer (CRLM). 2. Subjects must be able to provide informed consent themselves and without the use of a legally authorized representative (LAR), to be determined by the PI or Sub-I at the time of Consent. Exclusion: 1. Adults unable to consent 2. Pregnant Women 3. Certain clinical/surgical/anatomical parameters, at the discretion of the PI.

Design outcomes

Primary

Measure	Time frame	Description
Graft and Patient Survival Outcomes	From liver transplant to 12 months	Graft survival will be measured as the time from transplantation to graft failure, or re-transplantation date.

Secondary

Measure	Time frame	Description
Outcomes of liver transplant recipients	From liver transplant to 12 months	Evaluate outcomes (e.g., complications or surgical outcomes) of liver transplant (LT) recipients.

Countries

United States

Contacts

CONTACTYajaira Navarro

a-daud@northwestern.edu312-694-2092

Outcome results