Anal Squamous Cell Carcinoma, Human Papilloma Virus
Conditions
Brief summary
The majority of anal squamous cell carcinomas (SCC) stem from infection with high-risk human papillomavirus (HPV). Anal SCC is rare among the general population but affects several populations disproportionately. High-risk groups are screened through anal swabs for anal cytology and detection of high risk human papillomavirus (HR HPV). HRA referral is recommended for individuals with abnormal cytology. HRA represents the only method to identify precancerous lesions of the anal canal, with only few specialists knowledgeable about it. At UZ Brussel, the investigators collected a wealth of data about HPV infection and its association with anal pathology. By establishing a comprehensive study, the investigators can delve into this data with specific research questions, conducting valuable research to provide answers to pressing clinical questions and contribute to advancements in medical understanding and treatment.
Interventions
OTHERHRA
High resolution anoscopy to help evaluate anal conditions such as precancerous lesions
Sponsors
Universitair Ziekenhuis Brussel
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients who have undergone HRA and all future patients referred for HRA in UZ Brussel * 18 years or older * Understands and able to speak and write in French, Dutch or English
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| comparison of the prevalence of precancerous lesions in men who have sex with men using PrEP or are HIV positive Men | Through study completion, on average 5 years | — |
| Exploration of associations between abnormal histology and patient characteristics | Through study completion, on average 5 years | — |
| comparison of the prevalence of precancerous lesions in different groups | Through study completion, on average 5 years | — |
| to delineate unique features associated with HSIL in each risk group by linking patterns or characteristics | Through study completion, on average 5 years | such as verrucous aspects, coarse punctuation, mosaic patterns, flat morphology, and fragility |
| Prevalence of anal cancer among the at-risk populations | Through study completion, on average 5 years | — |
| correlation between abnormal histology and abnormal cytology, as well as HPV infection in MSM using PrEP and MSM living with HIV | Through study completion, on average 5 years | — |
Countries
Belgium
Contacts
Primary ContactMagali Surmont
Outcome results
None listed