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Post Bariatric Surgery Acute Kidney Injury: Incidence and Risk Factors

Post Bariatric Surgery Acute Kidney Injury: Incidence and Risk Factors

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06697743
Enrollment
30
Registered
2024-11-20
Start date
2024-12-01
Completion date
2027-02-28
Last updated
2024-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury, Bariatric Surgery

Keywords

Bariatric surgery, Acute kidney injury

Brief summary

Bariatric surgery is the most effective means of inducing and maintaining sustained weight loss. Apart from the weight loss effect, bariatric surgery leads to the remission of chronic metabolic disorders such as type 2 diabetes (T2D) and hypertension . Recent studies have shown that bariatric surgery improves renal perfusion and glomerular function and reduces inflammatory markers which can lead to an improvement of microalbuminuria and proteinuria However, acute kidney injury (AKI) can complicate the postoperative course after bariatric surgery. The etiology of AKI after bariatric surgery can be multifactorial and complex in obese population . The preexisting factors such as diabetes, hypertension, and CKD in these patients can additionally worsen the renal insult during the postoperative period . Postoperative AKI is associated with increase morbidity and mortality especially in cases of severe AKI that requires dialysis support . Identifying the high-risk patients for development of postoperative AKI would prevent renal injury. Our aim was to study the incidence and etiology of postoperative AKI after bariatric surgery . Causes of post bariatric surgery AKI include . Pre renal causes :dehydration ( repeated vomiting and diarrhoea)which are common complications post bariatric surgery , haemorrhagic shock (from the site of anastomosis , ulcer ) , septic shock ( leakage , pneumonia) , hypotension and respiratory depression secondary to narcotic overdose. Rena causes: contract induced nephropathy after using CT scan guided drainage of intra abdominal collection post operative, Rhabdomylosis , drug induced nephropathy e.g :using of IV vancomycin for sepsis in ICU .. many causes can lead to AkI post bariatric surgery but the common two causes are dehydration and sepsis .

Interventions

None listed

Sponsors

Assiut University
CollaboratorOTHER
Georgina Tharwat Abdelmasih
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

1. Inclusion criteria: 1. Age more than 18 years old undergo bariatric surgery . 2. BMI ≥30 : ( BMI = weight in kg / height in m²) 2.

Exclusion criteria

1. previous kidney diseases(AKI , CKD) . 2. patients unfit for surgery e.g ( comorbidities : CHD , LCF ) 3. Drugs : (ACE-I , ARBs, and NSAIDS)

Design outcomes

Primary

MeasureTime frameDescription
incidenceBaselineassess the incidence of postoperative AKI after bariatric surgery .
Risk factorsBaselineassess the risk factors of postoperative AKI after bariatric surgery

Secondary

MeasureTime frameDescription
duration of hospitalizationBaselineAssess the duration of hospitalization, and it's relation with the incidence of AKI
readmissionBaselineAssess the duration of readmission within 30 d after surgery and it's relation with the incidence of AKI

Contacts

Primary ContactGeorgina Tharwat Abdelmasih, Master
georginatharwat8@gmail.comgeorginatharwat8@gmail.com

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026