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Physiological Effects of Lung Impedance Tomography-Guided and Plat Pressure-Guided Phigh During APRV in Patients With ARDS

Physiological Effects of Lung Impedance Tomography-guided and Plat Pressure-guided Phigh During Airway Pressure Release Ventilation in Patients With Acute Respiratory Distress Syndrome

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06696638
Enrollment
26
Registered
2024-11-20
Start date
2025-01-01
Completion date
2026-12-31
Last updated
2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ARDS: Acute Respiratory Distress Syndrome

Keywords

ARDS, APRV, EIT, Phigh

Brief summary

This study aims to investigate the effects of EIT-guided and Pplat-guided Phigh settings on regional ventilation and perfusion in ARDS patients during APRV, while also examining the impact of different Phigh settings on gas exchange, respiratory mechanics, and hemodynamics.

Interventions

DEVICEEIT-guided Phigh settings during APRV

The Phigh level selected for the patients in the Intervention group was the intercept point of cumulated collapse and overdistension percentage curves, providing the best compromise between collapsed and overdistended lung.

Sponsors

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
CollaboratorOTHER
XiaoJing Zou,MD
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Diagnosed with ARDS according to the 2023 global new definition of ARDS. * Age ≥ 18 years.

Exclusion criteria

* Severe chronic obstructive pulmonary disease, severe asthma, pulmonary bullae, pneumothorax, subcutaneous emphysema, mediastinal emphysema, etc. · Contraindications for EIT, such as chest wound dressing, pacemaker implantation, defibrillator use, etc. * Pulmonary interstitial disease. * Uncorrected shock of various types. * Intracranial hypertension. * Pregnant and postpartum women.

Design outcomes

Primary

MeasureTime frame
The effects of Phigh guided by different methods on regional lung ventilation assessed by EIT1 Hour Post-Intervention

Secondary

MeasureTime frameDescription
Global inhomogeneity assessed by electrical impedance tomography1 Hour Post-Intervention—
Center of ventilation assessed by electrical impedance tomography1 Hour Post-Intervention—
ventilation/perfusion matching assessed by EIT1 Hour Post-Intervention—
Respiratory system compliance1 Hour Post-InterventionTidal volume divided by plateau pressure
mean arterial pressure1 Hour Post-Intervention—

Countries

China

Contacts

Primary Contactjing Xiao Zou
249126734@qq.com+862785351606

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026