Blood Volume Expansion
Conditions
Keywords
extra renal purification, bleeding, vascular filling
Brief summary
Venous overload has an impact on peripheral organ perfusion and on the short- and long-term prognosis of intensive care patients. The VExUS ultrasound score is a new tool whose parameters can be used to estimate this impact. This score was initially evaluated and validated on an adult population. ) In children, there is only one study looking at the use and applicability of this VExUS score, highlighting its feasibility in a paediatric population, as well as a possible correlation between elevated central venous pressure and altered renal Doppler (one of the score's components).
Interventions
OTHERVExUS evaluation ultrasound
VExUS evaluation by ultrasound will be performed before the filling/bleeding/cleaning procedure, and again after the procedure: * Inferior vena cava measurement in Time-Motion (TM) mode, 1-2 cm from the right atrial orifice. * Hepatic venous Doppler measurement in pulsed Doppler mode. * Renal vein Doppler measurement in pulsed Doppler mode. Each measurement is performed three times consecutively (to average the results), then the ultrasound measurements are compiled into a score according to the degree of doppler severity.
Sponsors
University Hospital, Toulouse
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
Children aged between 1 and 18 years, receiving extrarenal purification with UF \> 10 ml/kg, bleeding \> 10 ml/kg or vascular filling \> 10 ml/kg
Exclusion criteria
* Refusal of the patient or opposition of one or both holders of parental authority. * Minors with parental authority. * Ultrafiltration time \> 6h. * Curarized patient, known abnormality of the hepatorenal venous network. * Patient agitated or poor tolerance of the examination. * Parents under court protection, guardianship or curatorship.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in VExUS score | 10 minutes before en after the procedure of extrarenal purification, bloodletting or vascular filling | The correlation between ultrasound measurement of the VExUS score and the change in blood volume induced by extrarenal purification, bloodletting or vascular filling is studied. Ultrasound is performed before and after the procedure, each measure 3 times in succession, to establish the score. |
Countries
France
Outcome results
None listed