Glutamate Modulation of tDCS Over Premotor Cortex Combined With Peripheral Nerve Stimulation Promoted Observation-execution-related Cortical Excitability and Motor Learning

Glutamate Modulation of tDCS Over Premotor Cortex Combined With Peripheral Nerve Stimulation Promoted Observation-execution-related Cortical Excitability and Motor Learning

Status

Completed

Phases

NA

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06694909

Enrollment

128

Registered

2024-11-19

Start date

2017-10-17

Completion date

2018-10-14

Last updated

2024-11-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain Stimulation, Cortical Excitability, Motor Observation, Peripheral Nerve Stimulation

Brief summary

This study aimed to investigate whether concurrent tDCS over the PMC and PNS during action observation enhance observation-execution-related motor cortex excitability and improve motor performance, and to explore the underlying mechanism

Interventions

DEVICEtDCS + PNS with action observation

tDCS: transcranial direct current stimulation; PNS: peripheral nerve stimulation

DEVICEsham tDCS + sham PNS with action observation

tDCS: transcranial direct current stimulation; PNS: peripheral nerve stimulation

DEVICEtDCS + PNS without action observation

tDCS: transcranial direct current stimulation; PNS: peripheral nerve stimulation

DEVICEsham tDCS + PNS with action observation

tDCS: transcranial direct current stimulation; PNS: peripheral nerve stimulation

DEVICEtDCS + sham PNS with action observation

tDCS: transcranial direct current stimulation; PNS: peripheral nerve stimulation

Sponsors

Beijing Sport University

Lead SponsorOTHER

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 33 Years

Healthy volunteers

Yes

Inclusion criteria

* normal or corrected-to-normal vision * right-handed

Exclusion criteria

* pregnancy * a history of epilepsy * implanted medical devices * history or presence of neurological, psychiatric or musculoskeletal disorders, other medical conditions, and left-handedness

Design outcomes

Primary

Measure	Time frame
Motor-evoked potentials	Before interventions, and immediately after interventions
intracortical facilitation assessed by transcranial magnetic stimulation	Before interventions, and immediately after interventions
short-interval intracortical inhibition assessed by transcranial magnetic stimulation	Before interventions, and immediately after interventions
Reaction times of action execution blocks	immediately after interventions

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026