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Role of Oral Care in Prevention of Nosocomial Pneumonia Among COPD Patients

Routine Oral Care Versus Chlorhexidine Oral Care on Incidence of Nosocomial Pneumonia and Oral Health Among Critically Ill Non-intubated Patients With COPD

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06691399
Enrollment
60
Registered
2024-11-15
Start date
2024-10-01
Completion date
2025-06-01
Last updated
2024-11-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD Exacerbation, Nosocomial Pneumonia

Keywords

COPD, Oral care, Nosocomial pneumonia, Chlorhexidine

Brief summary

Poor dental hygiene has been linked to respiratory pathogen colonization in ICU patients. Therefore, respiratory pathogens tend to colonize dental plaque and oral mucosa in these populations. Therefore, strategies to eliminate respiratory pathogens from the oral cavity may improve oral hygiene and decrease the development of nosocomial pneumonia.

Detailed description

Infection is a common problem and a major cause of morbidity and mortality for patients in intensive care units (ICUs). Pneumonia is the most common site of infection according to an international study of the prevalence and outcomes of infection in ICUs, which included 13,796 patients. Nosocomial pneumonia (NP) is among the leading causes of mortality in patients in the ICU. Notably, the incidence of nosocomial pneumonia is increasing, and the number of infection-related deaths that follow is also increasing. Thus, preventing nosocomial pneumonia is a cost reducing and life-saving health care practice, especial in ICUs. Nosocomial pneumonia (NP) was defined as an infection of the lower respiratory tract that does not exist at the time of admission and does not have an incubation period of infection but occurs 48 hours after admission. The most important cause for the development of nosocomial pneumonia is the oral environment. The oral cavity of ICU patients is an important reservoir for bacteria and provides a habitat for microorganisms that can lead to nosocomial pneumonia. Patients in ICUs acquire pneumonia by aspirating oral bacteria that have been colonized in the oral cavity into the lower respiratory tract. Due to advanced age, limited mobility, illness, and cognitive dysfunction, patients in ICUs often have difficulty maintaining oral hygiene by themselves. Poor dental hygiene has been linked to respiratory pathogen colonization in ICU patients. Therefore, respiratory pathogens tend to colonize dental plaque and oral mucosa in these populations. Therefore, strategies to eliminate respiratory pathogens from the oral cavity may improve oral hygiene and decrease the development of nosocomial pneumonia. The aim of the present study is to assess value of preventive strategy using chlorhexidine for oral care among non-intubated COPD patients admitted to ICU upon incidence of nosocomial pneumonia.

Interventions

Oral care done twice daily with chlorhexidine oral care solution (concentration 1.2%)

Sponsors

Assiut University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Patients diagnosed as COPD * admitted to ICU with acute exacerbation * need for noninvasive ventilatory support including noninvasive ventilation anf high flow nasal cannula

Exclusion criteria

* patients refusing to participate * End stage organ failure (Heart Failure, Liver cell failure and/or Renal failure

Design outcomes

Primary

MeasureTime frameDescription
Incidence of nosocomial pneumonia1 monthIncidence of nosocomial pneumonia diagnosed via clinical features and confirmed with either chest ultrasonography or chest radiography

Countries

Egypt

Contacts

Primary ContactWaleed MD Gamal Elddin Khaleel, Ass. Prof.
waleed_gamal@aun.edu.eg+201006519722
Backup ContactMaiada MD Kamaleldin Hashem, Ass. Prof.
Maiada.hashem@aun.edu.eg+201006559662

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026