Recruitment, Respiratory Failure
Conditions
Brief summary
This single-center observational study aims to assess the effects of continuous high-frequency oscillation (CHFO) and continuous positive expiratory pressure (CPEP) therapy on lung recruitment using electrical impedance tomography (EIT) in spontaneously breathing patients admitted to the intensive care unit.
Interventions
PROCEDUREContinuous high-frequency oscillation (CHFO) and continuous positive expiratory pressure (CPEP) therapy
During application of CPEP and CHFO, EIT is monitored.
Sponsors
Denise Battaglini
University of Genova
Study design
Observational model
CASE_CROSSOVER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients who require pulmonary expansion and airway clearing as per clinical indication * Patients who provide valid informed consent according to local regulations * PaO2/FiO2 \< 200 mmHg at inclusion * Patient on the Airway Care Score (ACS) \< 7
Exclusion criteria
* Refuse to participate * Age \< 18 years * Hemodynamic instability, defined as systolic arterial pressure \< 90 mmHg or mean pressure \< 60 mmHg * Contraindication to using an EIT (i.e., pacemaker or defibrillator) * Inability to properly position the EIT device for anatomical reasons
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To assess changes in systemic oxygenation | Immediately before starting treatment (PEP or CHFO), immediately after the end of treatment, at 30 minutes after the end of treatment and at 60 minutes after the end of treatment | Arterial partial pressure of oxygen (PaO2, mmHg) and PaO2/FiO2 ratio (mmHg) |
| Changes in lung recruitment using EIT | Immediately before starting treatment (PEP or CHFO), immediately after the end of treatment, at 30 minutes after the end of treatment and at 60 minutes after the end of treatment | Absolute reduction in the percentage (%) of lung volume collapse assessed with the electrical impedance tomography (EIT) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mean arterial pressure, mmHg | Immediately before starting treatment (PEP or CHFO), immediately after the end of treatment, at 30 minutes after the end of treatment and at 60 minutes after the end of treatment | Heart rate as measured by continuous pressure monitoring |
| Heart rate min-1 | Immediately before starting treatment (PEP or CHFO), immediately after the end of treatment, at 30 minutes after the end of treatment and at 60 minutes after the end of treatment | Heart rate as measured by continuous electrocardiogram monitoring |
Countries
Italy
Contacts
Primary ContactDenise Battaglini, MD, PhD
Backup ContactLorenzo Ball, MD, PhD
Outcome results
None listed