Acute Kidney Injuries, Chronic Renal Diseases
Conditions
Keywords
Chronic renal disease, Acute kidney injury, Vitamin D
Brief summary
The investigators will be measuring vitamin D metabolites in blood samples drawn from patients undergoing cardiac surgery to determine the correlation with renal function as assessed by serum creatinine. The investigators will include 20 patients in each of the following 3 groups based on serum creatinine measured within 28-days of surgery: 1) normal kidney function (eGFR \> 60 mL/min, n=20), 2) moderate impaired kidney function, eGFR between 30 and 60 mL/min (n=20) and 3) severe kidney dysfunction eGFR \< 30 mL/min (n=20).
Interventions
None listed
Sponsors
University Health Network, Toronto
University of Toronto
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ≥ 18 years * Patients undergoing cardiac surgery * Serum Creatinine measured with 28 days of surgery
Exclusion criteria
* Exogeneous calcitriol (1,25(OH)2D3) intake * History of parathyroidectomy * Patients with liver or kidney cancer * Patients with liver disease (e.g. liver failure, cirrhosis)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Determine the correlation between eGFR as determined serum creatinine and vitamin D metabolites as markers of kidney function | Up to 1 month before surgery up until POD 7 | serum creatinine (sCr) and vitamin D metabolites (specifically 25(OH)D3 and 1,25(OH)2D3) will be measured in the same blood sample to determine the incidence of AKI and CKD in patients undergoing cardiac surgery |
Countries
Canada
Contacts
PRINCIPAL_INVESTIGATORStuart A McCluskey, MD, PhD
University Health Network, Toronto
Outcome results
None listed