Healthy Control
Conditions
Brief summary
The investigators are testing the impact of quiet sounds played during sleep on brain oscillations and memory.
Detailed description
Participants will undergo two visits with a memory task and nap. During one of the visits, quiet sounds will be played timed with sleep oscillations. During the other visit, no sounds will be played. Brain oscillations and memory will be measured at each visit.
Interventions
OTHERQuiet Sounds
Quiet sounds are played during sleep
OTHERSham Sounds
No sounds are played during sleep
Sponsors
Massachusetts General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
Adult -
Exclusion criteria
History of neurological disease, psychiatric disease, sleep apnea or sleep disorder. \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sleep spindle rate | 90 minutes | Sleep spindles are prominent thalamocortical brain oscillations seen on EEG during sleep that have been mechanistically linked to sleep-dependent memory consolidation. The sleep spindle rate over the course of the nap will be assessed using an automated spindle detector applied to the collected EEG sleep data. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Memory consolidation | 90 minutes | The motor sequence task (MST), a validated probe of memory consolidation, will be used to measure sleep-dependent memory consolidation. Participants will trained on MST before the nap opportunity and tested on MST after the nap opportunity to reliably measure memory consolidation. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORCatherine Chu, MD
Massachusetts General Hospital
Outcome results
None listed