Evaluation of Fractalkine and Its Receptor in Peri-implantitis

Evaluation of Fractalkine and Its Receptor in the Non-Surgical Treatment of Peri-implantitis

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06685523

Enrollment

100

Registered

2024-11-12

Start date

2024-11-08

Completion date

2025-05-15

Last updated

2024-11-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peri-implantitis

Keywords

Er:YAG laser, Debridment, peri-implantitis

Brief summary

In this study, mechanical debridement group, Er:YAG laser group and diode laser group will be compared in terms of reducing peri-implant sulcus depth in the treatment of peri-implantitis.

Interventions

PROCEDURESubgingival debridement

To be applied 1 times (0. days)

PROCEDUREEr:YAG laser decontamination

To be applied 3 times

PROCEDUREDiyot laser decontamination

To be applied 3 times

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Investigator, Outcomes Assessor)

Intervention model description

Four group: * Peri-implant healty * Mechanical curette * Er:YAG laser * Diyot laser

Eligibility

Sex/Gender

ALL

Age

40 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Probing depth of 4-6 mm, bone loss of at least 2 mm on X-ray and presence of inflammatory symptoms in soft tissue * No systemic disease that may affect the outcome of the treatment * Patients with healthy periodontium or patients with completed periodontal treatment * Individuals at least 6 months after prosthesis loading on the implant * Individuals who do not require further surgery for the treatment of peri-implantitis * Implants with at least 2 mm keratised gingiva * Individuals aged 40-60 years

Exclusion criteria

* Individuals undergoing radiation therapy * Individuals who smoke and drink alcohol * Individuals in pregnancy or lactation * Individuals who have received antibiotic treatment in the last three months * Individuals with parafunctional habits

Design outcomes

Primary

Measure	Time frame	Description
Probing depth, clinical attachment loss	sixth month	Measurement will be made with a periodontal probe. The unit of measurement is millimetre. The primary outcome measures are interrelated.

Secondary

Measure	Time frame	Description
gingival index, plaque index, sulcus blood index	sixth month	The 0,1,2,3 point system for index measurements is currently used in periodontology. These scores will be used in secondary outcome measures.

Countries

Turkey (Türkiye)

Contacts

Primary ContactKubilay Barış, Dr.

kubilaybaris60@hotmail.com+90-0553-973-64-77

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026