High Flow Nasal Canula, Premature Infant, Ventilation Therapy
Conditions
Brief summary
A prospective observational study evaluates the safety and efficacy of using High-Flow Nasal Cannula to stabilize extremely preterm infants immediately after birth. Following placental transfusion, high flow nasal cannula at 6-8 l/min is administered along with intermittent tactile stimulation. Criteria for switching to other interventions like continuous positive airway pressure or positive pressure ventilation are set for cases of persistent bradycardia or low Saturation of oxygen (SpO2).
Interventions
DEVICEHigh-Flow Nasal Cannula
The intervention involves administering High-Flow Nasal Cannula therapy to extremely preterm infants immediately after birth.
Sponsors
Charles University, Czech Republic
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
0 Minutes to 2 Minutes
Healthy volunteers
No
Inclusion criteria
* Preterm infants born between 25+0 and 27+6 gestational weeks * Weight above 500 grams
Exclusion criteria
* Previable rupture of membranes, * Congenital malformations previable * Acute intrauterine hypoxia.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Positive pressure ventilation after delivery | 10 minutes | The number of infants who required positive pressure ventilation (PPV) in the first ten minutes after delivery. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| SpO₂ > 80% in five minutes after delivery | 5 minutes | The number of infants with SpO₂ \> 80% five minutes after delivery, with or without the use of positive pressure ventilation (PPV). |
| SpO₂ > 90% ten minutes after delivery | 10 minutes | The number of infants with SpO₂ \> 90% ten minutes after delivery without the use of positive pressure ventilation (PPV). |
Countries
Czechia
Contacts
Primary ContactKlára Jonáš
Backup ContactRichard Plavka
Outcome results
None listed