Cardiovascular Diseases, Cardiovascular Diseases (CVD), Microvascular Dysfunction, Microvascular Health, Microvasculature, Obesity and Overweight
Conditions
Keywords
Obesity, Supplement
Brief summary
The goal of this study is to learn how a supplement Quercetin can affect microvascular function. Participants will: * give two blood draws of 5 mL each * have a camera placed under the tongue to take pictures of blood vessels * have 2 laser Doppler microdialysis catheters placed on the forearm to monitor blood vessels before and after local drug infusion Researchers will compare blood vessel function of those who take estrogen supplements to those who do not.
Interventions
DIETARY_SUPPLEMENTQuercetin (dietary supplement)
Quercetin will be provided to take one Quercetin per day for 30 days to look for differences in microvascular function.
DRUGPlacebo
Subjects randomized to receive placebo will be administered a standard placebo sugar pill.
Sponsors
Medical College of Wisconsin
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Intervention model description
Subjects will be randomized to receive the supplement quercetin or placebo for 30 days to determine its effect on microvascular function.
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Obesity (BMI\>30) * Aged 18-40 years * English Speaking
Exclusion criteria
* BMI\>60 * Resting SBP ≥180 mmHg or DBP ≥ 110mmHg * Pregnancy or breastfeeding. * Prior history of myocardial infarction * Diagnosis of more than 1 risk factor for coronary artery disease (active smoker, diabetes mellitus- type 1 or 2, congestive heart failure, hyperlipidemia, hypertension) * Active mouth sores that affect the buccal mucosa.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in blood vessel dilation | 2 hours | Peripheral microvascular dilation in response to acetylcholine, L-NAME, and sodium nitroprusside infusions will be measured using laser Doppler flowmetry with microdialysis. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Perfused Vessel Density | 0.5 hours | Total vessel density (TVD) will be calculated using the DeBacker Score manual analysis on all images that have a minimum microcirculation image quality score (MIQS) of 10. Perfused vessel density (PVD) will be calculated by multiplying total vessel density (TVD) x proportion of perfused vessels (PPV%). |
Countries
United States
Contacts
CONTACTJulia A Vogt
Outcome results
None listed