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Achieving Equity in Patient Outcome Reporting for Timely Assessments of Life With HIV and Substance Use

Achieving Equity in Patient Outcome Reporting for Timely Assessments of Life With HIV and Substance Use

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06682468
Acronym
ePORTAL-HIV-S
Enrollment
900
Registered
2024-11-12
Start date
2025-02-12
Completion date
2026-12-01
Last updated
2026-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV, Substance Use Disorders

Keywords

People Living with HIV, Screening, Substance Use Disorder Screening

Brief summary

This study aims to achieve health equity in substance use disorder (SUD) screening and treatment among people living with human immunodeficiency virus (HIV) by implementing interventions to decrease barriers to screening (clinic-based, in-person) and treatment (referral-focused), a program the study investigators call "Achieving Equity in Patient Outcome Reporting for Timely Assessments of Life With HIV and Substance Use (ePORTAL HIV-S)." The ePORTAL HIV-S randomized control trial will focus on portal-based screening in the HIV clinic, regardless of whether the patient has a scheduled appointment with their HIV provider.

Detailed description

Substance use disorder (SUD) and human immunodeficiency virus (HIV) are synergistic epidemics (syndemics) disproportionately affecting Black Americans. Structural racism related to inadequate access to healthcare, stigma, and criminalization, especially among those with intersectional identities related to gender and sexual minorities, further exacerbate disparities in HIV and SUD outcomes. SUD is often unrecognized and untreated among people living with HIV (PLWH). Only about half of HIV care sites routinely screen and refer to SUD treatment. In preliminary work, the study investigators found that nearly half of patients assessed in a HIV clinic waiting room met the criteria for a SUD, but 65% had not been diagnosed with SUD. A promising strategy to address structural barriers to SUD screening for PLWH is use of electronic patient portals. Patient portals are secure websites that give patients access to health information and allow for secure messaging with providers. They are associated with improved health outcomes and patient engagement. Notably, while most SUD screening currently occurs during clinic visits, portals can be utilized for SUD screening to reach patients who miss clinic visits, which is more common among people with HIV and SUD. The study team's preliminary work has demonstrated the potential of the portal for use in a population health approach to behavioral health screening. This study will implement and evaluate multi-level interventions to decrease barriers to SUD screening (clinic-based, in-person) and treatment (referral-focused), a program the study investigators call "Achieving Equity in Patient Outcome Reporting for Timely Assessments of Life With HIV and Substance Use (ePORTAL HIV-S)." ePORTAL HIV-S is conducting a randomized control trial to assess the effectiveness of population health vs. usual (clinic-visit) SUD screening among PLWH in a HIV clinic.

Interventions

BEHAVIORALPopulation level patient portal based substance involvement screening

Participants 18 years or older, with an active patient portal account, who have attended a HIV care clinic visit in the HIV clinic in the last two years and have not completed the validated NIDA Quick Screen V1.0 in the previous year will be eligible for intervention randomization. Those randomized into the intervention group will receive the validated NIDA Quick Screen V1.0 over their patient portal account. Participants randomized to this group can complete the screener over the patient portal without a scheduled appointment with their HIV clinician.

BEHAVIORALUsual Care Substance Use Involvement Screening

Participants randomized to the usual care group will receive the validated NIDA Quick Screen V1.0 during routine in-clinic visits if they attend their scheduled visit. The medical assistant will ask participants to complete the NIDA Quick Screen V1.0. Participants who endorse the use of illegal drugs or prescription drugs for non-medical reasons, tobacco use, or heavy drinking will be referred to SUD treatment.

Sponsors

University of Chicago
Lead SponsorOTHER
National Institute on Drug Abuse (NIDA)
CollaboratorNIH

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
SINGLE (Investigator)

Masking description

Patient randomization will be completed by an honest broker and blinded to the research team.

Intervention model description

Participants will be enrolled into two groups: intervention and standard care. Patients randomized to the intervention arm will not be blinded to the intervention and will receive the NIDA Quick Screen via MyChart and at clinic appointments. Patients randomized to the usual care group will receive the NIDA Quick Screen during appointments with their clinicians and, thus, be blinded to trial assignments. HIV clinicians have been informed of the intervention and will not be informed of the randomization assignment. Still, clinicians will receive NIDA Quick Screen results when the patient completes the screener via MyChart.

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* 18 years or older * has been diagnosed with human immunodeficiency virus infection (HIV) * provider has assented * receives HIV care at the University of Chicago Ryan White Adult HIV Care Clinic, as evidenced by inclusion in the Epic HIV Registry * speaks English * has not completed in clinic SUD screening in the last year * has an active MyChart account

Exclusion criteria

* Patients who have been screened for substance use disorder at the clinic in the last year using the NIDA Quick Screen * Patient's provider has not assented to the intervention * Patient is younger than 18 years

Design outcomes

Primary

MeasureTime frameDescription
Percentage of participants screened for substance use disorder1 year from screening start datePercentage of participants who completed the validated NIDA Quick Screen V1.0 for substance use disorder in the HIV clinic.

Secondary

MeasureTime frameDescription
Retention in care in the year post-screening2 years from screening start date\# of participants who attended HIV care clinic visit in the year after completing the NIDA Quick Screen V1.0
HIV viral suppression1 year from screening start dateParticipants' labs of HIV viral load measurements
Number and percentage of participants referred to substance use and misuse treatment1 year from screening start date\# of participants referred to substance use and misuse treatment / # of participants diagnosed with moderate or high risk of substance use involvement
Number and percentage of participants with moderate or high risk of substance involvement1 year from screening start dateThe number and percentage of participants who receive a score of 4 or higher in illicit substance use, say "Yes" to one or more days of heavy drinking, or endorse tobacco use, indicating moderate or high risk of substance involvement measured by the NIDA Quick Screen V1.0.

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORJessica P. Ridgway, MD, MS

University of Chicago

PRINCIPAL_INVESTIGATORNeda Laiteerapong, MD, MS

University of Chicago

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 11, 2026