Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy

Postoperative Heme Oxygenase Induction and Carbon Monoxide Production as a Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06681818

Enrollment

125

Registered

2024-11-08

Start date

2025-11-21

Completion date

2039-01-01

Last updated

2025-07-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Cancer Adult, Liver Regeneration

Keywords

hepatectomy

Brief summary

the investigators will pursue two specific aims: (1) to monitor the extent of heme oxygenase induction (by measuring endogenous CO production) in relationship to the extent of hepatic resection (2) to assess the production of CO in patients following liver resection and correlate these findings to the rate of liver regeneration and liver function.

Interventions

OTHERcarbon monoxide measurement via smokerlyzer

participants in this study will provide breath samples for carbon monoxide measurements pre and post liver resection

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patient plans to have partial liver resection for primary liver pathology or metastatic disease * Patient is able to comprehend and willing to sign the written consent form

Exclusion criteria

* Patients \< 18 years * Patients identified as members of a vulnerable population, except women of child bearing potential with negative pregnancy test

Design outcomes

Primary

Measure	Time frame	Description
correlation of carbon monoxide levels in exhaled breath with quantity and quality of liver regeneration	measurements will be taken pre, then 4 hours and 24 hours post resection	patients will be asked to donate exhaled breath into a smokerlyzer device

Secondary

Measure	Time frame	Description
level of carbon monoxide in exhaled air of patients	measurements will be taken pre, then 4 hours and 24 hours post resection	patients will be asked to donate exhaled breath into a smokerlyzer device
quantity of liver regeneration, liver volume (ml)	one and three months after resection	CT liver volumetric studies
quality of hepatic regeneration, normalized liver function	one and three months post resection	serum protein, albumin, AST and ALT, alkaline phosphatase, and bilirubin level

Countries

United States

Contacts

Primary ContactJamie Ketas

jamie.ketas@ehmchealth.org2018943418

Backup ContactRaquel Molina

raquel.molina@ehmchealth.org

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026