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Raspberry Ketone Intake Upregulates Circulating FGF21 and Induces Energy Expenditure in Humans

The Effect of Raspberry Ketone Intake on Plasma FGF21 Levels

Status
Completed
Phases
Early Phase 1
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06681597
Enrollment
60
Registered
2024-11-08
Start date
2024-01-10
Completion date
2024-06-01
Last updated
2024-11-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes, NAFLD (Nonalcoholic Fatty Liver Disease), Obesity

Brief summary

To investigate the molecular mechanism of raspberry ketone on regulating obesity, the investigators studied the effect of raspberry ketone intake on FGF21 in plasma. The age of the volunteers were 18-60 years old, both male and female, without diabetes, hypertension and other diseases. After ingestion of raspberry ketone (500mg), 2ml of blood was collected at 0 hours, 3 hours and 6 hours , and the FGF21 content in plasma was measured using a commercial reagent kit. In addition, the investigators also studied the effect of raspberry ketone intake on energy metabolism 0 hours, 0.5 hours, 3 hours and 6 hours after consuming raspberry ketone (500mg).

Interventions

DIETARY_SUPPLEMENTRaspberry ketone

Human consumed 500mg of raspberry ketone

Sponsors

Nanchang University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
Yes

Inclusion criteria

No drugs were taken before the human study

Exclusion criteria

Patients with hypertension

Design outcomes

Primary

MeasureTime frameDescription
Impact of raspberry ketone consumption on energy expenditureThrough study completion, an average of 1 yearThe oxygen consumption, heart rate, carbon dioxide production were measured
Impact of raspberry ketone consumption on plasma FGF21 levelThrough study completion, an average of 1 year

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026