Compare the Concentration of Exhaled Nitric Oxide in Patients With Different Severity of RF
Conditions
Brief summary
1. Main Objective: To compare the concentration of exhaled nitric oxide in patients with different severity of respiratory failure in ICU. 2. Secondary Purpose: 1. To observe the change of nitric oxide concentration in exhaled breath of patients with mechanical ventilation over time; 2. The relationship and differences between pulmonary ventilation blood flow levels in patients with different exhaled NO concentrations; 3. Reactivity of patients with different exhaled NO concentrations to inhaled nitric oxide therapy and the relationship between them.
Interventions
OTHERFeNO Observation
FeNO was observed and measured among patients with advanced respiratory support
Sponsors
Shanghai Zhongshan Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Inclusion criteria
1. Adult patients (≥18 years of age) with mechanical ventilation or advanced respiratory support in the ICU, regardless of gender; 2. The expected mechanical ventilation time of tracheal intubation is more than 24 hours; 3. The initial ventilator Settings of clinical routine were adopted: oxygen fraction (FIO2) = 50%, respiratory rate = 15/min, positive end-expiratory pressure (PEEP) = 5 cmH2O, tidal volume = 6-8 ml/kg ideal body weight (IBW), inspiration-exhalation ratio =1:2; 4. Agree to participate in this experiment and sign the informed consent.
Exclusion criteria
* 1.Use of any NO-containing drugs (such as nitroglycerin), anti-inflammatory drugs, or drugs or means that affect the airway diameter within 6 hours before the first FeNO measurement; 2. Participating in other clinical research projects; 3. Patients deemed unsuitable by the investigators.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| FeNO concentration | 1.5 year | Exhaled nitric oxide concentration of patients with different severity of respiratory failure in ICU |
Countries
China
Contacts
Primary ContactHuan Wang, Master
Outcome results
None listed