Community-Acquired Pneumonia, Vitamin a
Conditions
Keywords
Community-acquired pneumonia, Vitamin A, Pediatrics, Hospitalization, Southern Iran
Brief summary
This randomized clinical trial included 105 children with CAP who were admitted to Bandar Abbas Children's Hospital. Participants were randomly assigned to two groups: a control group receiving standard antibiotic therapy and an intervention group receiving standard antibiotics plus vitamin A (25,000 IU for 2 days). Key data collected included age, sex, duration of hospitalization, treatment duration, and daily Respiratory Index of Severity in Children (RISC) scores.
Detailed description
Children to present with CAP symptoms
Interventions
DIETARY_SUPPLEMENTVitamin A
the intervention group received standard antibiotics plus adjunctive vitamin A supplementation (25,000 IU daily for two days)
Sponsors
Hormozgan University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Intervention model description
This randomized clinical trial included 105 children with CAP who were admitted to Bandar Abbas Children's Hospital. Participants were randomly assigned to two groups: a control group receiving standard antibiotic therapy and an intervention group receiving standard antibiotics plus vitamin A (25,000 IU for 2 days).
Eligibility
Sex/Gender
ALL
Age
6 Months to 12 Years
Healthy volunteers
Yes
Inclusion criteria
* children to present with CAP symptoms, including fever, cough, pulmonary rales, respiratory distress (age-adjusted tachypnea: \>50 breaths per minute for infants under 1 year, \>40 for ages 1-5 years, and \>30 for those over 5 years), and radiographic findings indicative of pneumonia.
Exclusion criteria
* underlying immunodeficiency, chronic respiratory conditions, concurrent use of immunosuppressive medications, prior high-dose vitamin A intake, and hospitalizations shorter than 24 hours
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| duration of hospitalization | Key data collected included age, sex, duration of hospitalization, treatment duration, and daily Respiratory Index of Severity in Children (RISC) scores. | Vitamin A supplementation was associated with a significant reduction in hospitalization duration in children with CAP, supporting its potential as an adjunct therapy. |
| Treatment duration daily Respiratory Index of Severity in Children (RISC) scores | From enrollment to the end of treatment and discharge of patients ( 6 months) | daily Respiratory Index of Severity in Children (RISC) scores |
Countries
Iran
Outcome results
None listed