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Effect of Low-Level Laser on Crevicular Interleukin-1β Concentration in Patients With Periodontal Disease: A Relation to Periodontal Inflammaging

Effect of Low-Level Laser on Crevicular Interleukin-1β Concentration in Patients With Periodontal Disease: A Relation to Periodontal Inflammaging

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06677385
Enrollment
28
Registered
2024-11-06
Start date
2023-07-12
Completion date
2024-10-12
Last updated
2025-02-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Old Age, Periodontal Diseases

Brief summary

This study is done to compare between young age and old age patients with periodontitis (inflammaging) and the effect of diode laser as adjunctive to scaling and debridement

Interventions

diode laser as adjunctive to conventional scaling and debridement for old age patients

conventional scaling and debridement

Sponsors

Misr University for Science and Technology
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

1. Male or Female 2. Aged below 40 or above 60. 3. Provide informed consent and willingness to cooperate with study protocol. 4. Periodontitis stage II patients: * CAL from 3-4 mm. * Radiographic bone loss (15% to 33%). * No tooth loss due to periodontitis. * Maximum probing depth ≤ 5 mm, mostly horizontal bone loss

Exclusion criteria

1. Patients with heavy smoking habits 2. History of antibiotics in the previous three months. 3. Pregnant or lactating female. 4. Treatment with any systemic drug. 5. History of systemic disease. 6. Patients who received periodontal treatment in the last 6 months

Design outcomes

Primary

MeasureTime frameDescription
Gingival indexfirst visit, second follow up after 1 month and final follow up after 6 months
Clinical attachment lossfirst visit, second follow up after 1 month and final follow up after 6 months
Interleukin 1 betafirst visit, second follow up after 1 month and final follow up after 6 monthscollected and analyzed by ELISA from Gingival crevicular fluid and blood serum

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026