Difficult-to-Wean Patients
Conditions
Keywords
mechanical ventilation, electrical impedance tomography
Brief summary
Diaphragm dysfunction, ineffective chest wall and respiratory muscle function are frequently observed in critically ill patients with difficult weaning from mechanical ventilation(MV).It is the leading cause of retention of airway secretions and insufficient airway clearance.Thechest physiotherapy (CPT) of critically ill patients can reduce secretion retention. We designed a protocol to investigate the feasibility and efficacy of CPT guided by electrical impedance tomography (EIT) in Difficult-to-Wean patients.
Interventions
Two sessions of CPT (morning and afternoon, 20 minutes each) were conducted. The CPT session consisted of modified postural drainage, assisted cough technique , positive expiratory pressure and chest percussion, vibration. The appointed therapist performed pulmonary auscultation and thoracic palpation to assess the status of pulmonary ventilation and secretion retention, and whether the patient's cough ability can complete effective airway clearance. Individualized program was formed according to the assessment, internal guidelines, the patient's tolerance, education level, and patient's preference prior to the randomization. All CPT sessions were performed by the same physiotherapist to avoid potential bias.
EIT-guided modified postural drainage combined with vibrations and chest percussion: tidal variation images in EIT reveals heterogeneously ventilated regions. Physiotherapist identified such regions at the bedside and instructed the patient to take the appropriate drainage position, so that the poorly ventilated regions became gravity non-dependent regions. Subsequently, the physiotherapist put her hands on the poorly ventilated area with a vibratory force. A compressive pressure was produced by the therapist's arms.
Sponsors
Study design
Eligibility
Inclusion criteria
* mechanical ventilation patients who are ≥18 years old, are received to invasive mechanical ventilation more than 96 hours before randomization, are meted the preconditions for the machine to be withdrawn, and at least have one failed attempt to withdraw the ventilator (re-need ventilator support within 48 hours after extubation), * willing to participate in the study and sign the informed consentsent.
Exclusion criteria
* Malignant arrhythmia or acute myocardial ischemia * Pneumothorax, pulmonary bulla and barotrauma and other lung diseases * Hemorrhagic disease or abnormal coagulation mechanism with bleeding tendency * Chest skin trauma * Pulmonary hypertension and pulmonary embolism * With a permanent or temporary pacemaker * There is malignant tumor * Present and previous history of neuromuscular diseases affecting respiratory muscle * Participated in another clinical study related to mechanical ventilation withdrawal * Can not cooperate with the study for any reason or the researcher thinks that it is not suitable to be included in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| peak expiratory flow | All data will be recorded at the baseline (T1), 14 days (T2) and 28 days (T3) |
Secondary
| Measure | Time frame |
|---|---|
| Maximum inspiratory pressure | All data will be recorded at the baseline (T1), 14 days (T2) and 28 days (T3) |
| Diaphragm thickening rate | All data will be recorded at the baseline (T1), 14 days (T2) and 28 days (T3) |
| The cumulative incidence of successful weaning by Day 30 | from admission to discharge, assessed up to 1 day |
| Length of ICU stay | from admission to discharge, assessed up to 1 day |
| Cumulative incidence for death before successful weaning | from admission to discharge, assessed up to 1 day |
| Diaphragmatic excursion | All data will be recorded at the baseline (T1), 14 days (T2) and 28 days (T3) |