Changes in Pulse-Oximetry Perfusion Index Induced by Tidal Volume Challenge Versus Fluid Volume Challenge to Detect Preload Responsiveness in Mechanically Ventilated Patients With Low Tidal Volume

Changes in Pulse-Oximetry Perfusion Index Induced by Tidal Volume Challenge Versus Fluid Volume Challenge to Detect Preload Responsiveness in Mechanically Ventilated Patients With Low Tidal Volume: A Prospective Observational Study

Status

Enrolling by invitation

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06673862

Enrollment

Registered

2024-11-05

Start date

2024-09-01

Completion date

2025-02-28

Last updated

2024-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

To Assess the Ability of PI to Detect Preload Responsiveness

Keywords

fluid responsiveness, VTI, PI, tidal volume challenge, fluid challenge, perfusion index, velocity time index, preload responsiveness

Brief summary

The primary goal of this study was to assess the ability of PI changes induced by a Vt challenge or fluid challenge test to detect preload responsiveness in critically ill adult patients on mechanical ventilation with low-tidal volume. The secondary aims were (i) to compare the changes in PI with VTI during a Vt challenge test (ii) to compare the changes in VTI and PI during a volume expansion challenge test, (iii) to compare the Vt-induced changes in PI to changes induced by fluid challenge test, (iv) to compare the Vt-induced changes in VTI to changes induced by fluid challenge test.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Patients of both genders aged 18 years or older Invasive mechanical ventilation in assist controlled mode with a Vt of 6 mL/kg PBW, Patients with circulatory failure Decision by the clinicians in charge to assess preload responsiveness through a Vt Challenge and a Fluid Challenge test. Patients in sinus rhythm

Exclusion criteria

Open chest Pulmonary hypertension Poor lung compliance (Crs \<30 ml/cmH2O) Obesity (BMI≥35) Pregnancy Intraabdominal hypertension Prone position Atrial fibrillation

Design outcomes

Primary

Measure	Time frame	Description
The ability of perfusion index to detect preload responsiveness	Approximately one hour	The primary goal of this study was to assess the ability of PI changes induced by a Vt challenge or fluid challenge test to detect preload responsiveness in critically ill adult patients on mechanical ventilation with low-tidal volume.

Secondary

Measure	Time frame
Compare the changes in PI with VTI during a Vt challenge test	Approximately one hour
Compare the changes in VTI and PI during a volume expansion challenge test	Approximately one hour
Compare the Vt-induced changes in PI to changes induced by fluid challenge test	Approximately one hour

Other

Measure	Time frame
Compare the Vt-induced changes in VTI to changes induced by fluid challenge test	Approximately one hour

Countries

Egypt

Outcome results