Comparison Between Atenolol,Propnalol and Ivabradine

Comparison Between Atenolol , Propnalol and Ivabradine as a Premedication for Bloodless Field Anesthesia in Lumbar Spine Surgery ,a Prospective Randomized Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06670690

Enrollment

120

Registered

2024-11-01

Start date

2023-09-01

Completion date

2023-10-01

Last updated

2024-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intraoperative Bleeding

Brief summary

The aim of this work is to compare atenolol, propranolol, and ivabradine as a premedication to achieve bloodless field anesthesia primarily controlling heart rate in lumbar spine surgery.

Detailed description

This study will investigate the effect of atenolol, propranolol, and ivabradine as oral premedication in adult patients undergoing LUMBAR SPINE SURGERY to achieve bloodless field anesthesia. AIM OF THE WORK * The primary aim of this work is to compare atenolol, propranolol, and ivabradine as a premedication to achieve bloodless field anesthesia primarily controlling heart rate in lumbar spine surgery. * The secondary aims are to assess field visibility and measure the amount of blood loss in patients, and surgeon satisfaction and also to asses if there are any associated undesirable side effects of atenolol, propranolol, or Ivabradine will appear.

Interventions

DRUGAtenolol 50 MG

patients will be premedicated with atenolol (50mg)

DRUGPropranolol Pill

patients will be premedicated with propranolol (10mg)

DRUGIvabradine

patients will be premedicated with Ivabradine (5mg)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* ASA physical status I and II, * aged from 18 to 50 years old * scheduled for elective lumber spine surgeries will be included in this study.

Exclusion criteria

* Hypertension. * Hepatic or renal disease. * Diabetes Mellitus. * Pregnancy. * Coagulation disorders. * Anemia (Hb \< 10 g/dL). * Ischemic heart disease * Drug or alcohol abuse. * Allergy to any of atenolol, propranolol, and ivabradine. * History of beta-blockers, calcium channel blockers, Tricyclic antidepressants, anticoagulant or clonidine intake.

Design outcomes

Primary

Measure	Time frame	Description
Perioperative Heamodynamic Effect of the drugs	every 5 minutes for 15 minutes and then every 10 minutes till end of surgery, then every 15 minutes for 1hour in the recovery room	Heart rate

Secondary

Measure	Time frame	Description
Blood loss & surgical field visibility score	Intraoperative time	quality scale proposed by Fromm and Boezaart
Anesthetic consumption	Intraoperative time	Propofol, opioid, and isoflurane consumption
Incidence of complication	Intraoperative time	The patient will be examined for bradycardia, or tachycardia hypo or hypertension, shivering, respiratory depression, dizziness, visual disturbance, nausea, and vomiting
The need for blood transfusion	Intraoperative time	The need for blood transfusion

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026